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Showing 1–17 of 17 results
Advanced filters: Author: Satchal K. Erramilli Clear advanced filters

  • Cryo-electron microscopy structures of the bacterial O-antigen ligase WaaL, combined with genetics, biochemistry and molecular dynamics simulations, provide insight into the mechanism by which WaaL catalyses the biosynthesis of lipopolysaccharide.

    • Khuram U. Ashraf
    • Rie Nygaard
    • Filippo Mancia
    Research
    Nature
    Volume: 604, P: 371-376

  • A linkage-specific tool for K29-linked polyubiquitin was developed, enabling the discovery that K29-linked ubiquitination participates in multiple cellular pathways, including the proteotoxic stress response and cell cycle regulation.

    • Yuanyuan Yu
    • Qingyun Zheng
    • Minglei Zhao
    Research
    Nature Chemical Biology
    Volume: 17, P: 896-905

  • Bacterial resistance to polymyxin antibiotics is conferred by enzymes such as phosphoethanolamine transferases, which add positively charged phosphoethanolamine to lipid A. Here, the authors present the structure of one such enzyme in its liganded form, and propose an enzymatic mechanism that may be generally applicable to other phosphoform transferases.

    • Allen P. Zinkle
    • Mariana Bunoro Batista
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Here, the authors present cryoEM structures of AftB, a key mycobacterial enzyme that adds terminal arabinose residues to the cell wall. In concert with functional assays and MD simulations, mechanistic insights are presented.

    • Yaqi Liu
    • Chelsea M. Brown
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs) in Mycobacterium tuberculosis.

    • Yaqi Liu
    • Chelsea M. Brown
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Vaults are massive, cytoplasmic, cage-like ribonucleoprotein assemblies. Here, authors describe cryo-EM structures of human vault encapsulating PARP4 & nucleotide ligands, as well as proteomic data showing that depleting PARP4 alters the vault interactome.

    • Jane E. Lodwick
    • Rong Shen
    • Minglei Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Hyaluronan (HA) is an essential glycosaminoglycan. Here, the authors provide mechanistic insights into how HA synthase synthesizes HA and creates a membrane-spanning secretion channel, as well as how channel-lining residues modulate the HA length distribution.

    • Ireneusz Górniak
    • Zachery Stephens
    • Jochen Zimmer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 161-171

  • Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.

    • Jonathan Kim
    • Yong Zi Tan
    • Filippo Mancia
    Research
    Nature
    Volume: 576, P: 315-320

  • The cryo-electron microscopy structure of the membrane-embedded ubiquitin ligase complex reveals its function as a retrotranslocation channel for shuttling mobile receptors out of peroxisomes.

    • Peiqiang Feng
    • Xudong Wu
    • Tom A. Rapoport
    ResearchOpen Access
    Nature
    Volume: 607, P: 374-380

  • Human proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce viral infectivity. Here, the authors show that SERINC3 has architecture resembling non-ATP dependent lipid transporters and induces loss of membrane asymmetry correlated with changes in envelope conformation and loss of infectivity.

    • Susan A. Leonhardt
    • Michael D. Purdy
    • Mark Yeager
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Single particle cryo-electron microscopy of membrane proteins is limited by their small size and difficulty to orient. Here the authors generate recombinant antibodies against the 12 kDa fusion partner BRIL domain from apocytochrome b562 to use them as plug and play fiducial marks for structure determination of BRIL fused membrane proteins.

    • Somnath Mukherjee
    • Satchal K. Erramilli
    • Anthony A. Kossiakoff
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • A synthetic antibody fragment is engineered, capable of binding to human claudin-4, providing insights into its structure and selective binding mechanism, possibly enabling precise modulation of tight junctions in tissue-specific therapeutic interventions.

    • Satchal K. Erramilli
    • Pawel K. Dominik
    • Alex J. Vecchio
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-16