Here the authors investigate the significance of endothelial C-type natriuretic peptide (CNP) and its receptor GCB in the development of pulmonary hypertension using multiple models. They show that endothelial CNP/GC-B signaling suppresses vasoproliferative and inflammatory pathways, thereby limiting vascular remodeling.
- Hiromu Yanagisawa
- Koichiro Kuwahara
- Koh Ono
