The present study demonstrated that the higher difference of morning and evening home systolic blood pressure (SBP) (MEdif: morning minus evening home SBP ≥ 20 mmHg) was associated with higher total cardiovascular disease (CVD) events risk compared with other MEdif groups. After adjusting confounding factors and average of morning and evening home SBP (MEave), the higher MEdif group showed higher CVD risk compared with the normal MEdif group (0–20 mmHg) (adjusted hazard ratio [HR] 1.38, 95% confidence interval [CI] 1.01–1.88). The both elevated MEave (≥135 mmHg) and MEdif (≥20 mmHg) groups were also associated with higher CVD risk compared to the both controlled groups (adjusted HR 1.64, 95% CI 1.10–2.47). From these findings, the higher MEdif in home BP monitoring was suggested to predict future CVD incidence.
- Keisuke Narita
- Satoshi Hoshide
- Kazuomi Kario
