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Showing 1–8 of 8 results
Advanced filters: Author: Saverio Capuano Clear advanced filters

  • Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

    • Karla K. Ausderau
    • Ben Boerigter
    • Emma L. Mohr
    ResearchOpen Access
    Nature Communications
    P: 1-17

  • Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are explored.

    • Ranjith P. Anand
    • Jacob V. Layer
    • Wenning Qin
    ResearchOpen Access
    Nature
    Volume: 622, P: 393-401

  • Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.

    • Dawn M. Dudley
    • Matthew T. Aliota
    • David H. O’Connor
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

    • Christina M. Newman
    • Dawn M. Dudley
    • Thomas C. Friedrich
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

    • Dawn M. Dudley
    • Christina M. Newman
    • Matthew T. Aliota
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Indian rhesus macaques are vaccinated with simian immunodeficiency virus (SIV)-restricted CD8+ T-cell epitopes, and these vaccinated animals are shown to mediate elite control of virus replication.

    • Philip A. Mudd
    • Mauricio A. Martins
    • David I. Watkins
    Research
    Nature
    Volume: 491, P: 129-133