Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature Communications (2)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (2)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biophysics
Chemistry
Computational biology and bioinformatics

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–2 of 2 results

Advanced filters: Author: Sean Boult Clear advanced filters

Decoding the substrate specificity landscape of a promiscuous enzyme through multi-substrate mutational scanning

Using mutational scanning, this study maps how thousands of mutations alter substrate specificity in the promiscuous enzyme D-amino acid oxidase, and reveals catalytic-site and long-range effects that inform the design of highly selective biocatalysts.

Rosario Vanella
Sean Boult
Michael A. Nash
ResearchOpen Access26 Feb 2026
Nature Communications

P: 1-17
Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization

Sperm–egg adhesion is crucial for mammalian reproduction. Here, authors report the human Izumo1:Juno complex, a key regulator of sperm-egg adhesion, forms an unusually strong bond through a secondary binding site, which is impaired in an infertility-associated Juno mutant.

Sean Boult
Paulina Pacak
Michael A. Nash
ResearchOpen Access26 Aug 2025
Nature Communications

Volume: 16, P: 1-17

Search

Search articles by subject, keyword or author

Show results from

Advanced search

Quick links

Explore articles by subject
Find a job
Guide to authors
Editorial policies

Nature.com

nature.com footer links

About Nature Portfolio

About us
Press releases
Press office
Contact us

Discover content

Journals A-Z
Articles by subject
protocols.io
Nature Index

Publishing policies

Nature portfolio policies
Open access

Author & Researcher services

Reprints & permissions
Research data
Language editing
Scientific editing
Nature Masterclasses
Research Solutions

Libraries & institutions

Librarian service & tools
Librarian portal
Open research
Recommend to library

Advertising & partnerships

Advertising
Partnerships & Services
Media kits
Branded content

Professional development

Nature Awards
Nature Careers
Nature Conferences

Regional websites

Nature Africa
Nature China
Nature India
Nature Japan
Nature Middle East

Privacy Policy
Use of cookies
Legal notice
Accessibility statement
Terms & Conditions
Your US state privacy rights

Search

Filter By:

Decoding the substrate specificity landscape of a promiscuous enzyme through multi-substrate mutational scanning

Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization

Search

Quick links