Search

Plant traits drive ecosystem dynamics yet are challenging to map globally due to sparse measurements. Here, the authors combine crowdsourced biodiversity observations with Earth observation data to accurately map 31 plant traits at 1 km² resolution.

Er³⁺ is implanted into CaWO₄, a material with non-polar site symmetry free of background rare earth ions, to realize reduced optical spectral diffusion in nanophotonic devices, representing a step towards making telecom band quantum repeater networks with single ions.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Quantum systems make it challenging to determine candidate Hamiltonians from experimental data. An automated protocol is presented and its capabilities to infer the correct Hamiltonian are demonstrated in a nitrogen-vacancy centre set-up.

The authors demonstrate the detection of ¹H ¹H J-couplings, which are difficult to observe in the solid state, in plastic crystals of camphor using solid state NMR at magic angle spinning rates of 100 kHz and above.

As presented at AHA Scientific Sessions 2025, in a trial emulation analysis including benchmarking to data from randomized clinical trials, treatment with semaglutide and tirzepatide showed similar levels of benefit on cardiovascular outcomes in individuals at elevated cardiovascular risk with obesity and diabetes.

CMOS-based circuits can be integrated with silicon-based spin qubits and can be controlled at milli-kelvin temperatures, which can potentially help scale up these systems.

A negatively charged nitrogen–vacancy centre — a promising quantum light source — is created in diamond by laser writing (with pulses with a central wavelength of 790 nm and duration of 300 fs) with an accuracy of 200 nm in the transverse plane.

A single dose of an adeno-associated virus vector encoding an HIV-1 broadly neutralizing antibody given shortly after birth results in persistent antibody expression and protection from infection in rhesus macaque models of human HIV-1 transmission through breastfeeding and sexual intercourse.

Here the authors combine a multimodal imaging-snRNAseq transcriptomics strategy to provide insight into the distribution of a neurotropic tick-borne flavivirus in the brain, and show that absence of interferon signaling increases infection of resident microglia.

Several recent studies suggest that telomerase has key physiologic functions beyond its well-known role telomere maintenance. Here, Garcia Gonzalez et al. implicate telomerase in the regulation of ribosomal DNA transcription by RNA polymerase I.

The interaction between spins in magnetic materials gives rise to a number of interesting effects. An example is the discovery of an unusual magnetic state based on a long-range ordering force between magnetic domain walls that is analogous to the interaction between protons and neutrons in atomic nuclei.

Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist longer than in adults.

Dietary restriction (DR) late in life does not improve survival and has little benefit in metabolic health in mice. The absence of a DR gene-expression signature in fat tissue suggests that a ‘nutritional memory’ interferes with the benefits of DR.

We report organic molecules showing both efficient luminescence and near-unity generation yield of excited states with high spin multiplicity, simultaneously supporting a high efficiency of initialization, spin manipulations and light-based readout at room temperature.

Increases in transcriptional elongation speed with age affect organismal lifespan and ageing-related changes could be reversed with lifespan-extending interventions.

The canonical metal-organic framework ZIF-8 does not melt and form a glass. Here, authors incorporated two additional organic linkers into ZIF-8 to generate meltable derivatives which can be transformed into highly porous glasses by melt-quenching.

p63 activation in response to DNA damage leads to oocyte death and loss of fertility in women receiving chemotherapy. Activation requires sequential phosphorylation by CHK2 and CK1 kinases, and inhibition of these kinases rescues oocytes from apoptosis induced by chemotherapy.

Self-propelling micro/nanomotors represent a therapeutic option for drug delivery. Here the authors report the design and characterization of a biodegradable urease-powered nanomotor containing STING agonist, promoting anti-tumor immune responses in bladder cancer models.

Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.

Using brain organoids models, Prigione and colleagues uncovered the impact of Huntington’s disease on human brain developmental and identified early dysregulation of CHCHD2, which disrupted mitochondria and might serve as a therapeutic target.

Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR^G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase remains susceptible to second-generation inhibitors.

Spatz and colleagues report that intercellular pulling forces between leader and follower cells in migrating epithelial sheets regulate merlin subcellular localization and the crosstalk between merlin and Rac1 to promote collective cell migration.

Responsive liquid systems which exhibit a breathing behaviour and show step-shaped gas sorption isotherms, akin to the distinct oxygen saturation curve of haemoglobin in blood have been developed. Their breathing behaviour upon sorption of industrially relevant gases is demonstrated.

More transparent protocol reporting and comprehensive battery cell data are needed. Twenty-one research groups joined forces to assess solid-state battery performance and found considerable differences in assembly protocols that cause variable results.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Glasses derived from meltable metal-organic frameworks (MOFs) offer great potential for gas separation and solid state ionics. Here, the authors quantify the porosity of a series of MOF glasses by cryogenic carbon dioxide gas sorption and propose design principles for rational tuning the glasses‘ pore size and pore volume.

Leigh syndrome (LS) is a severe neurometabolic disorder which lacks effective models. Here, the authors developed human neuronal models of LS carrying mutations in SURF1 which show impaired neuronal morphogenesis due to metabolic deficiencies.

Singlet fission is a promising carrier multiplication process, where a singlet exciton is split in two triplet states. Here the authors propose an oxygen-assisted two-step mechanism for singlet fission accounting for ~ 40% triplet quantum yield in dilute solutions where the single-step mechanism is inactive.

How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in response to high levels of extracellular Ca2+ and this pathway might be critical to inflammatory conditions.

The authors show that plasma levels of NfL increase with age in humans and are associated with mortality in nonagenarians and centenarians. In mice, a life-extending dietary restriction manipulation attenuated the similar age-related increase in plasma NfL levels.

ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

The mechanisms that control the suppressive function of T_reg cells in specific tissues are unclear. Bopp and colleagues show that T_reg cells have high expression of kinase CK2 and this is critical for their ability to suppress type 2 responses in the lungs.

KRAS is a proto-oncogene that is mutated in a wide variety of human cancers. Although this makes KRAS an obvious candidate for the development of targeted therapies, it has so far remained refractory to this approach. Systematic RNA interference is now used to detect synthetic lethal partners of oncogenic KRAS, revealing that TBK1 and NF-κB signalling are essential in KRAS mutant tumours. This may provide an alternative approach for targeting KRAS therapeutically.

Skyrmions in synthetic antiferromagnets are appealing for use in future memory and computing devices, combining small size and fast motion, but creating, stabilizing, and observing them remains a challenge. Here, Juge et al demonstrate the stabilization and current and light induced nucleation of skyrmions in a synthetic antiferromagnet, observing the magnetization texture in each layer using X-ray magnetic microscopy.

The application of photoswitches as light-responsive triggers for phase transitions of porous materials remains poorly explored. Here, the authors report a light-responsive flexible metal-organic framework which undergoes pore contraction upon combined application of light irradiation and adsorption stress via a buckling process of the framework-embedded azobenzene photoswitch.

The general transcription factors TFIIE and TFIIH subunit Ssl2/XPB function in the transition of the preinitiation complex (PIC) to the open polymerase II (Pol II) complex. Efforts to localize TFIIE and Ssl2 in the yeast PIC now reveal crucial roles for the three TFIIE winged-helix domains and for Ssl2 in promoting DNA strand separation.

Integrated devices are useful for applications like sample stabilization, microscopy, adaptive optics, and acceleration sensors. Here the authors demonstrate a fully integrated chip-scale light-based displacement sensor using Huygens dipole scattering of light.

Giant submarine gravity flows are a key mechanism in global sediment transport, yet their properties remain enigmatic. Here, the authors reconstruct the properties of a historic giant submarine gravity flow from deposits across the seafloor.

Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand age-related molecular changes.

HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of another Nef molecule, which allows them to propose a model how Nef recognizes these motifs in CD3 and CD4.

A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

There is a strong correlation between submarine slope failures and the occurrence of gas hydrates. Here, the authors use a combination of seismic data and numerical modelling to show that overpressure at the gas hydrate stability zone leads to potential destabilization of the slope and submarine landslides.