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Showing 1–18 of 18 results
Advanced filters: Author: Serge Mostowy Clear advanced filters

  • Cellular microbiology is a field that combines the study of infection and cell biology. In this review, we highlight emerging technologies and infection models that recently transformed our understanding of the infected cell and may inspire future medicine.

    • Ana Teresa López-Jiménez
    • Serge Mostowy
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • New infections of the amphibian chytrid fungus could arise from other animal reservoirs in the environment. Here, Liewet al. demonstrate that zebrafish can be infected by chytrid similarly to amphibians, expanding our understanding of how this pathogen can parasitize its hosts.

    • Nicole Liew
    • Maria J. Mazon Moya
    • Serge Mostowy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Experts in the field met at the London School of Hygiene & Tropical Medicine (UK) to discuss the role of zebrafish in advancing fundamental research and discovering therapeutic innovations.

    • Vincenzo Torraca
    • Margarida C. Gomes
    • Serge Mostowy
    Comments & Opinion
    Lab Animal
    Volume: 48, P: 284-287

  • Septins are cytoskeletal proteins that assemble into complexes and contribute to immunity by entrapping intracellular bacteria in cage-like structures. Here, Lobato-Márquez et al. reconstitute septin cages in vitro using purified recombinant complexes, and study how these recognize bacterial cells and assemble as filaments on their surface.

    • Damián Lobato-Márquez
    • Jingwei Xu
    • Serge Mostowy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide mutagenesis screening, reveals virulence factors required for Shigella colonization.

    • Sydney L. Miles
    • Serge Mostowy
    News & Views
    Nature Genetics
    Volume: 57, P: 1568-1570

  • Shigella, an important human pathogen, can secrete effector proteins to invade host cells and evade mechanisms of cell-autonomous immunity. In a new manuscript published in Nature Communications, Xian et al. report that the Shigella kinase effector OspG promotes the ubiquitination of septin cytoskeletal proteins to evade cage entrapment.

    • Ana T. López-Jiménez
    • Gizem Özbaykal Güler
    • Serge Mostowy
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 15, P: 1-3

  • Raman spectroscopic imaging (RSI) can provide information on the chemical composition of a sample, but application to living organisms has lacked sufficient spatial resolution and signal strength. Here the authors apply confocal RSI to whole-mount zebrafish embryos to distinguish different infectious bacteria and to living zebrafish embryos to monitor the wound healing process.

    • Håkon Høgset
    • Conor C. Horgan
    • Molly M. Stevens
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Septins are highly conserved, GTP-binding proteins that form hetero-oligomeric complexes and higher-order structures, such as filaments and rings. By acting as scaffolds or diffusion barriers, they have roles in numerous biological processes, including cell division and host–pathogen interactions.

    • Serge Mostowy
    • Pascale Cossart
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 183-194

  • The reservoir for recurrent urinary tract infection in humans is unclear. Here, Mickiewicz et al. detect cell-wall deficient (L-form) E. coli in fresh urine from patients, and show that the isolated bacteria readily switch between walled and L-form states.

    • Katarzyna M. Mickiewicz
    • Yoshikazu Kawai
    • Jeff Errington
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Voinnet and colleagues show that autophagy targets RNAi components DICER and AGO2 for degradation when they are not bound to miRNA. The autophagy receptor NDP52 is required for this homeostatic regulation of the RNAi machinery. The authors also found that autophagy influences the post-translational regulation of DICER mRNA.

    • Derrick Gibbings
    • Serge Mostowy
    • Olivier Voinnet
    Research
    Nature Cell Biology
    Volume: 14, P: 1314-1321

  • Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.

    • Pamela P. Lee
    • Damián Lobato-Márquez
    • Adrian J. Thrasher
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • In this Review, Scott et al. review our current knowledge of Shigella sonnei, highlighting recent insights into this globally disseminated antimicrobial-resistant pathogen and assessing how novel data may have an impact on future vaccine development and implementation.

    • Timothy A. Scott
    • Kate S. Baker
    • Stephen Baker
    Reviews
    Nature Reviews Microbiology
    Volume: 23, P: 303-317