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Showing 1–13 of 13 results
Advanced filters: Author: Seth L. Shipman Clear advanced filters

  • This protocol describes the use of Retro-Cascorder to make temporally resolved transcriptional recordings in Escherichia coli DNA, using a retron reverse transcriptase to store transcriptional events in a unidirectionally expanding CRISPR array via acquisition by CRISPR–Cas integrases.

    • Sierra K. Lear
    • Santiago C. Lopez
    • Seth L. Shipman
    Protocols
    Nature Protocols
    Volume: 18, P: 1866-1892

  • González-Delgado et al. developed retron-based editors termed multitrons, which can modify multiple sites on a single genome simultaneously. This technology is compatible with recombineering in prokaryotes and CRISPR editing in eukaryotes with applications in molecular recording, genome minimization and metabolic engineering.

    • Alejandro González-Delgado
    • Santiago C. Lopez
    • Seth L. Shipman
    Research
    Nature Chemical Biology
    Volume: 20, P: 1482-1492

  • Bacteriophage single-stranded DNA annealing proteins (SSAPs) interact with the C termini of single-stranded binding proteins in host bacteria, a finding that enables engineering of enhanced SSAP portability and DNA recombineering activities.

    • Gabriel T. Filsinger
    • Timothy M. Wannier
    • George M. Church
    Research
    Nature Chemical Biology
    Volume: 17, P: 394-402

  • The cumbersome encoding of digital data to cellular DNA hinders the use of cells as living hard drives. A new approach transfers digital information directly into cellular DNA by converting electrical signals into stable and interpretable changes in the genomes of bacterial populations.

    • Santi Bhattarai-Kline
    • Sierra K. Lear
    • Seth L. Shipman
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 232-233

  • Neuroligins are important for synaptogenesis and are thought to influence postsynaptic assembly via binding to PSD-95. In rat organotypic hippocampal slices treated to reduce endogenous neuroligin, the authors find that the C-terminal tail of neuroligin is critical for its function.

    • Seth L Shipman
    • Eric Schnell
    • Roger A Nicoll
    Research
    Nature Neuroscience
    Volume: 14, P: 718-726

  • This study shows that neuroligin-1, a trans-synaptic cell adhesion molecule for excitatory synapses, is directly phosphorylated by Ca2+/CaM kinase II in a neuronal activity–dependent manner in vitro and in vivo. The authors also show that this post-translational modification of neuroligin-1 regulates excitatory synaptic potentiation.

    • Michael A Bemben
    • Seth L Shipman
    • Katherine W Roche
    Research
    Nature Neuroscience
    Volume: 17, P: 56-64