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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.

Edgar Gonzalez-Kozlova
Robert Sweeney
Sacha Gnjatic
ResearchOpen Access27 Jan 2026
Nature Medicine

P: 1-14
Human assembloids recapitulate periportal liver tissue in vitro

Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.

Lei Yuan
Sagarika Dawka
Meritxell Huch
ResearchOpen Access17 Dec 2025
Nature

P: 1-12
The association between serum sodium level and tuberculous meningitis compared with viral and bacterial meningitis

Seunghee Na
Taewon Kim
Woojun Kim
ResearchOpen Access25 May 2021
Scientific Reports

Volume: 11, P: 1-7
Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption during peripheral inflammation in mice, mediated by CXCL-dependent neutrophil recruitment.

Sung-Hyun Yoon
Chae youn Kim
Je-Wook Yu
ResearchOpen Access15 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.

Nambin Yim
Seung-Wook Ryu
Chulhee Choi
ResearchOpen Access22 Jul 2016
Nature Communications

Volume: 7, P: 1-9
Myocardial infarction augments sleep to limit cardiac inflammation and damage

Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic signalling and assists healing.

Pacific Huynh
Jan D. Hoffmann
Cameron S. McAlpine
Research30 Oct 2024
Nature

Volume: 635, P: 168-177
Suppressed N₂O formation during NH₃ selective catalytic reduction using vanadium on zeolitic microporous TiO₂

Seung Gwan Lee
Hyun Jeong Lee
Sung June Cho
ResearchOpen Access03 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial

In a phase 2 trial, the combination of gemcitabine, cisplatin and anti-PD-1 led to a clinical complete response in 43% of patients with muscle-invasive bladder cancer, which facilitated bladder sparing and was associated with long-term bladder-intact metastasis-free survival.

Matthew D. Galsky
Siamak Daneshmand
Sumanta K. Pal
ResearchOpen Access02 Oct 2023
Nature Medicine

Volume: 29, P: 2825-2834
Nintedanib ameliorates animal model of dermatitis

Min-Jeong Heo
Chanmi Lee
Jin Hyuk Jung
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-8
Characterization of a new selective glucocorticoid receptor modulator with anorexigenic activity

Junekyoung Lee
Yeonghun Song
Seunghee Lee
ResearchOpen Access03 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Effect of Mechanical Stretch on the DNCB-induced Proinflammatory Cytokine Secretion in Human Keratinocytes

Seunghee Oh
Hyewon Chung
Hyungsuk Lee
ResearchOpen Access26 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Fat3 regulates neural progenitor cells by promoting Yap activity during spinal cord development

Soyeon Seo
Young A. Kim
Seunghee Lee
ResearchOpen Access30 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
3′-Sialyllactose alleviates bone loss by regulating bone homeostasis

3′-Sialyllactose alleviates the progression of osteoporosis by regulating bone homeostasis and may have a therapeutic effect as an anti-osteoporosis agent.

Ahreum Baek
Dawoon Baek
Sung-Rae Cho
ResearchOpen Access19 Jan 2024
Communications Biology

Volume: 7, P: 1-15

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