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Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contributing to this severe disease complication.

Lingjia Kong
Sathish Subramanian
Ramnik J. Xavier
Research25 Jun 2025
Nature Genetics

Volume: 57, P: 1742-1753

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Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network

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