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A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin

C16orf74/ calcimembrin (CLMB), a lipidated microprotein with roles in cancer, targets the calcineurin phosphatase to membranes. Here, authors show how CLMB uses a composite motif to form multimeric complexes with calcineurin that are required for dephosphorylation.

Devin A. Bradburn
Joana C. Reis
Martha S. Cyert
ResearchOpen Access12 Nov 2025
Nature Communications

Volume: 16, P: 1-14
Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

Andrzej T. Slominski
Tae-Kang Kim
Yuhua Song
ResearchOpen Access13 Apr 2021
Scientific Reports

Volume: 11, P: 1-23

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A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

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