The mechanism of respiratory viral infection impacting distant immune responses in the uterus remains to be explored. The authors here identify pulmonary infection induces IL1R2⁺ myeloid cells migration to decidua, disrupting gestational immunity. Dipeptidyl peptidase 4 (DPP4) inhibitor treatment curbs this cell accumulation and alleviates immune dysregulation.
- Guirong Shi
- Shengdi Xi
- Binqing Fu
