Nature Search

BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression

Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.

Weizhi Zhang
Shuhang Liang
Lianxin Liu
ResearchOpen Access11 May 2026
Nature Communications

P: 1-19
Quantum anomalous Hall effect from intertwined moiré bands

An electric-field-induced topological phase transition from a Mott insulator to a quantum anomalous Hall insulator in near-60-degree-twisted (or AB-stacked) MoTe₂/WSe₂ heterobilayers is reported.

Tingxin Li
Shengwei Jiang
Kin Fai Mak
Research22 Dec 2021
Nature

Volume: 600, P: 641-646
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

Ning Zhang
Linmao Sun
Lianxin Liu
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Giant spin Hall effect in AB-stacked MoTe₂/WSe₂ bilayers

A giant spin Hall effect with long spin diffusion length and coexisting with ferromagnetism is observed in AB-stacked MoTe₂/WSe₂ moiré hetero-bilayers.

Zui Tao
Bowen Shen
Kin Fai Mak
Research17 Aug 2023
Nature Nanotechnology

Volume: 19, P: 28-33
Intrinsic spin Hall torque in a moiré Chern magnet

Switching of magnetic behaviour is one of the main ideas that drives spintronics. Now, magnetic switching via spin-orbit torque is shown in a moiré bilayer, introducing a platform for spintronic applications.

C. L. Tschirhart
Evgeny Redekop
A. F. Young
Research09 Mar 2023
Nature Physics

Volume: 19, P: 807-813
Improved snow geese algorithm for engineering applications and clustering optimization

Haihong Bian
Can Li
Zhiyuan Zhang
ResearchOpen Access06 Feb 2025
Scientific Reports

Volume: 15, P: 1-95
Size-fractionated microbiome observed during an eight-month long sampling in Jiaozhou Bay and the Yellow Sea

Jianchang Tao
Wenxiu Wang
Shengwei Hou
ResearchOpen Access07 Oct 2022
Scientific Data

Volume: 9, P: 1-8
Publisher Correction: Size-fractionated microbiome observed during an eight-month long sampling in Jiaozhou Bay and the Yellow Sea

Jianchang Tao
Wenxiu Wang
Shengwei Hou
Amendments and CorrectionsOpen Access13 Oct 2022
Scientific Data

Volume: 9, P: 1
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8⁺T cells function in the HCC microenvironment

Cheng Cheng
Qingrui Zha
Lianxin Liu
ResearchOpen Access24 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-18
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

Wei Zhang
Guoyu Yin
Xinyu Yang
ResearchOpen Access20 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-14

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