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Showing 1–3 of 3 results
Advanced filters: Author: Shibai Li Clear advanced filters

  • Smc5/6 association with DNA junctions can support genomic functions. Here, the authors show that Smc5/6 junction polarity preferences, targeting, and dwell times are determined by its structural modules as well as the RPA and PCNA genomic factors.

    • Jeremy T-H. Chang
    • Victoria Miller-Browne
    • Xiaolan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Using single-molecule visualization and manipulation, Chang et al. show that the eukaryotic Smc5/6 complex preferentially binds to and stabilizes ssDNA-dsDNA junctions, which could serve as the molecular basis for its diverse roles in genome maintenance.

    • Jeremy T-H. Chang
    • Shibai Li
    • Shixin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The DNA damage checkpoint needs to be turned off to allow cellular recovery from genotoxic exposure. Here, the authors report that the scaffold proteins Rtt107 and Mms22 and their associated ubiquitin ligase enable this downregulation and reduces the level of a key checkpoint mediator Rad9.

    • Bingbing Wan
    • Danying Guan
    • Xiaolan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12