How site-specific tumor microenvironment (TME) drives the metastasis of high-grade serous ovarian cancer (HGSOC) remains unclear. Here, the authors employ an integrated single cell multi-omics approach to map the spatiotemporal heterogeneity of HGSOC metastasis TME and identify an interaction network within the TME driven by SELENOP+ macrophages and pre-exhausted CD8+ T cells.
- Qing Liu
- Chenzhao Feng
- Xin Zhou
