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Showing 1–9 of 9 results
Advanced filters: Author: Shinji Irie Clear advanced filters

  • While diet is essential for daily nutrient acquisition, excessive intake of sugar-rich foods drives obesity and related health issues like diabetes. Here, the authors show that commensal bacterium S. salivarius curbs obesity by transforming dietary sugars into beneficial compounds.

    • Hidenori Shimizu
    • Junki Miyamoto
    • Ikuo Kimura
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Mammalian cell-based cultured meat has mostly been unstructured, leaving a demand for artificial steak-like meat. Here the authors present an assembled steak-like tissue of bovine skeletal muscle, adipose tissue, and blood capillary tissue fabricated by tendon-gel integrated printing technology.

    • Dong-Hee Kang
    • Fiona Louis
    • Michiya Matsusaki
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The authors investigate the in vivo function of microRNA-124a by specifically disrupting Rncr3, the dominant source of miR-124a in mice. Their results suggest that miR-124a is important for maturation and survival of dentate gyrus neurons and retinal cones and acts by repressing Lhx2 translation.

    • Rikako Sanuki
    • Akishi Onishi
    • Takahisa Furukawa
    Research
    Nature Neuroscience
    Volume: 14, P: 1125-1134

  • Pursuing high Curie temperature magnetic insulators has been one of the extensively studied subjects due to their wide appeal for spintronic applications. Here the authors experimentally and theoretically demonstrate a record high Curie temperature over 1000 K in B-site ordered double-perovskite, Sr3OsO6.

    • Yuki K. Wakabayashi
    • Yoshiharu Krockenberger
    • Hideki Yamamoto
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

    • Kazuo Kitagawa
    • Hisatomi Arima
    • Seigo Nakada
    Research
    Hypertension Research
    Volume: 45, P: 591-601

  • Daisuke Oikawa et al. provide structural insights into how small-molecule inhibitors of LUBAC ubiquitin ligase, HOIPINs, bind to LUBAC. They find that HOIPINs trigger apoptosis in lymphoma cells and alleviate psoriasis in mice, suggesting the potential therapeutic utility of HOIPINs.

    • Daisuke Oikawa
    • Yusuke Sato
    • Fuminori Tokunaga
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-17

  • RAFT aqueous emulsion polymerization of vinyl acetate (VAc) was performed using poly[di(ethylene glycol) vinyl ether] (PDEGV) macromolecular chain transfer agents. The emulsion polymerization directly induced PDEGV-b-PVAc diblock copolymer assemblies in water. Owing to the characteristic PDEGV as a highly hydrophilic steric stabilizer, this facile formulation enables the production of various particle morphologies, such as spheres, rods (ellipsoids), and vesicles, depending on the composition of the block copolymer. Each morphology change in the nanoparticles via RAFT aqueous emulsion polymerization owes its success to the recent RAFT polymerizations of vinyl ethers.

    • Shinji Sugihara
    • Ryuya Kawakami
    • Yasushi Maeda
    Research
    Polymer Journal
    Volume: 53, P: 309-321