Nature Search

A cross-population compendium of gene–environment interactions

A large cross-population atlas of gene–environment interactions reveals how age, sex and lifestyle shape genetic effects, heritability, prediction accuracy and disease biology, with implications for personalized medicine and drug development.

Shinichi Namba
Kyuto Sonehara
Yukinori Okada
ResearchOpen Access28 Jan 2026
Nature

P: 1-10
Y chromosome analysis for common surnames in the Japanese male population

Eriko Ochiai
Motoki Osawa
Kiyoshi Minaguchi
Research01 Feb 2021
Journal of Human Genetics

Volume: 66, P: 731-738
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.

Takafumi Suzuki
Shiori Seki
Masayuki Yamamoto
ResearchOpen Access24 Feb 2017
Nature Communications

Volume: 8, P: 1-13
An atlas of active enhancers across human cell types and tissues

Using the FANTOM5 CAGE expression atlas, the authors show that bidirectional capped RNAs are a signature feature of active enhancers and identify over 40,000 enhancer candidates from over 800 human cell and tissue samples across the whole human body.

Robin Andersson
Claudia Gebhard
Albin Sandelin
Research26 Mar 2014
Nature

Volume: 507, P: 455-461
Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Jun Kunisawa
Makoto Arita
Hiroshi Kiyono
ResearchOpen Access11 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Surgical and functional outcomes of robot-assisted versus laparoscopic partial nephrectomy with cortical renorrhaphy omission

Masashi Kubota
Toshinari Yamasaki
Mutsushi Kawakita
ResearchOpen Access29 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Kuchitsu et al. show that STING-positive vesicles of a recycling endosome origin are encapsulated into lysosomes after STING ubiquitination and this process requires ESCRT proteins Tsg101 and Vps4.

Yoshihiko Kuchitsu
Kojiro Mukai
Tomohiko Taguchi
ResearchOpen Access13 Mar 2023
Nature Cell Biology

Volume: 25, P: 453-466
Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants

A SARS-CoV-2 antibody, NT-108, exhibits potent therapeutic effects in vivo. Cryo-EM structure of the spike complexed with single-chain Fv of NT108 reveals its neutralizing mechanism, providing insight into antibody therapeutic design.

Yuki Anraku
Shunsuke Kita
Katsumi Maenaka
ResearchOpen Access22 Mar 2025
Communications Biology

Volume: 8, P: 1-12
Microbe-dependent CD11b⁺ IgA⁺ plasma cells mediate robust early-phase intestinal IgA responses in mice

Intestinal plasma cells contribute to the delicate balance between immunity against pathogens and tolerance of intestinal microflora. Kunisawa et al. identify a subpopulation of plasma cells whose proliferation depends on stimulation by microbes and IL-10, and which mediate early-phase responses to oral antigens.

Jun Kunisawa
Masashi Gohda
Hiroshi Kiyono
ResearchOpen Access23 Apr 2013
Nature Communications

Volume: 4, P: 1-10
Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cdc7.

Chi-Chun Yang
Masahiro Suzuki
Hisao Masai
ResearchOpen Access12 Jul 2016
Nature Communications

Volume: 7, P: 1-14
GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation

An integrated analysis of human induced pluripotent stem cells differentiating into hepatocyte-like cells unveils changes in DNA methylation and relevant transcription factors (like GATA6) that may influence hepatic development.

Takahiro Suzuki
Erina Furuhata
Harukazu Suzuki
ResearchOpen Access04 May 2022
Communications Biology

Volume: 5, P: 1-12
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Regression of Atherosclerosis by Amlodipine via Anti-Inflammatory and Anti-Oxidative Stress Actions

Toyofumi Yoshii
Masaru Iwai
Masatsugu Horiuchi
Research01 Jun 2006
Hypertension Research

Volume: 29, P: 457-466
A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells

Yuki Tanaka
Erina Furuhata
Takahiro Suzuki
ResearchOpen Access14 Feb 2023
Scientific Data

Volume: 10, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body

Shiori Awa
Genjiro Suzuki
Masato Hasegawa
ResearchOpen Access21 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy

Shiori Ando
Shunya Suzuki
Hideaki Hara
ResearchOpen Access15 Oct 2020
Scientific Reports

Volume: 10, P: 1-16
Maternal excess dietary phosphate intake in the periconceptional period is a potential risk for mineral disorders in offspring mice

Mayu Hayashi-Suzuki
Shiori Fukuda-Tatano
Yutaka Taketani
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-16
Degradation behavior in soil and mechanical properties of bagasse monoesters with different acyl chain lengths and residual hydroxy contents

Shiori Suzuki
Shogo Ishikura
Kenji Takahashi
ResearchOpen Access26 Mar 2025
Polymer Journal

Volume: 57, P: 761-769
Author Correction: Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

Misaki Inoue
Kiyoka Matsumoto
Mitsuhiro Nakamura
Amendments and CorrectionsOpen Access28 Nov 2022
Scientific Reports

Volume: 12, P: 1-2
Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident

Yusuke Urushihara
Toshihiko Suzuki
Manabu Fukumoto
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

Yoko Yamagiwa
Keitaro Tanaka
Shuhei Nomura
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-12
Rapid and facile quantification of surface amino groups on chitin nanowhiskers and nanofibers via spectrophotometry

Surface amino groups (SAGs) on nanochitin materials were quantified using three amino-labeling reagents and two cationic dyes. After binding to SAGs, the excess labeling reagents or generated molecules were assessed by spectrophotometry. The dyes were adsorbed onto SAGs, and the excess was similarly quantified. The obtained values were compared with the titration values. Although the values by labeling reagents were underestimated, some of the values were proportional to those by titration. Reliable results were attained using the two labeling reagents with conversion equations or using Acid Orange 7 adsorption.

Jun Araki
Shiori Yoda
Riku Kudo
Research25 Mar 2024
Polymer Journal

Volume: 56, P: 705-710
Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Akiko Hanyuda
Atsushi Goto
Motoki Iwasaki
ResearchOpen Access29 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

Ryoko Katagiri
Atsushi Goto
Motoki Iwasaki
ResearchOpen Access10 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort

Shiori Suzuki
Ryoko Katagiri
H. Yatsuya
Research10 Feb 2022
British Journal of Cancer

Volume: 126, P: 1481-1489
Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

Misaki Inoue
Kiyoka Matsumoto
Mitsuhiro Nakamura
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-11
Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle

Mariko Morii
Sho Kubota
Naoto Yamaguchi
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Dry-jet wet spinning of β-1,3-glucan and α-1,3-glucan

Regenerated fibers of β-1,3-glucan (curdlan) and α-1,3-glucan were fabricated by dry-jet wet spinning, and the fiber properties and structures are summarized in this review. The flexible and water-absorbent curdlan and the stiff and strong α-1,3-glucan would be utilized in different applications from conventional cellulose. As a new type of post-treatment, a two-step stretching method in water was developed for α-1,3-glucan by utilizing its crystal transition. This can be applied to various polysaccharides for future production of high-performance fibers.

Shiori Suzuki
Azusa Togo
Tadahisa Iwata
Reviews10 Nov 2021
Polymer Journal

Volume: 54, P: 493-501
Whole exome sequencing of fetal structural anomalies detected by ultrasonography

Hiromi Aoi
Takeshi Mizuguchi
Naomichi Matsumoto
Research03 Nov 2020
Journal of Human Genetics

Volume: 66, P: 499-507
Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale

Kobayashi-Sun et al. characterise the healing of fractured bone in the transgenic zebrafish scale by transplantation assays and live imaging, revealing that immature osteoclasts engulf osteoblast-derived extracellular vesicles (EVs) under fracture stress, leading to osteoclast differentiation. This study provides insights into the role of EVs in osteoclastogenesis.

Jingjing Kobayashi-Sun
Shiori Yamamori
Isao Kobayashi
ResearchOpen Access23 Apr 2020
Communications Biology

Volume: 3, P: 1-12
Production of marmoset eggs and embryos from xenotransplanted ovary tissues

Runa Hirayama
Hiroaki Taketsuru
Kenji Sakimura
ResearchOpen Access24 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
The NanoSuit method: a novel histological approach for examining paraffin sections in a nondestructive manner by correlative light and electron microscopy

The NanoSuit method permits the study of paraffin sections using correlative light and electron microscopy at low and high magnification, with the following features: (i) the integrity of the glass slide is maintained, (ii) 3D microstructures of tissue and pathogens can be visualized, (iii) nuclei and 3,3′-diaminobenzidine-stained areas are distinct because of gold chloride usage, (iv) immunohistochemical staining is quantitative, and (v) contained elements can be analyzed.

Hideya Kawasaki
Toshiya Itoh
Takahiko Hariyama
ResearchOpen Access29 Aug 2019
Laboratory Investigation

Volume: 100, P: 161-173
Flame-retardant plant thermoplastics directly prepared by single ionic liquid substitution

We developed flame-retardant thermoplastics directly from biomass just by dissolution into ionic liquids and precipitation. During the dissolution, a phosphonate-type ionic liquid adducted on the polymers included in biomass such as cellulose through reaction of the hydroxyl groups. In this method, more than 86% of the hydroxy groups were maintained after ionic liquid substitution because the single phosphonate-type ionic liquid acted as a plasticizer and flame retardant in the plant biomass. Therefore, the plant biomass-derived flame-retardant thermoplastics have the potential for further functionalization.

Ryunosuke Nishita
Kosuke Kuroda
Kenji Takahashi
Research17 Apr 2019
Polymer Journal

Volume: 51, P: 781-789

Search

A cross-population compendium of gene–environment interactions

Y chromosome analysis for common surnames in the Japanese male population

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

An atlas of active enhancers across human cell types and tissues

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut

Surgical and functional outcomes of robot-assisted versus laparoscopic partial nephrectomy with cortical renorrhaphy omission

STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants

Microbe-dependent CD11b⁺ IgA⁺ plasma cells mediate robust early-phase intestinal IgA responses in mice

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Regression of Atherosclerosis by Amlodipine via Anti-Inflammatory and Anti-Oxidative Stress Actions

A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body

Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy

Maternal excess dietary phosphate intake in the periconceptional period is a potential risk for mineral disorders in offspring mice

Degradation behavior in soil and mechanical properties of bagasse monoesters with different acyl chain lengths and residual hydroxy contents

Author Correction: Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident

Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies

Rapid and facile quantification of surface amino groups on chitin nanowhiskers and nanofibers via spectrophotometry

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach

Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort

Analysis of chemotherapy-induced peripheral neuropathy using the Japanese Adverse Drug Event Report database

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle

Dry-jet wet spinning of β-1,3-glucan and α-1,3-glucan

Whole exome sequencing of fetal structural anomalies detected by ultrasonography

Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale

Production of marmoset eggs and embryos from xenotransplanted ovary tissues

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

The NanoSuit method: a novel histological approach for examining paraffin sections in a nondestructive manner by correlative light and electron microscopy

Flame-retardant plant thermoplastics directly prepared by single ionic liquid substitution

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