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Showing 1–50 of 125 results

Advanced filters: Author: Shizuo Akira Clear advanced filters

Assessment of dysplasia in bone marrow smear with convolutional neural network

Jinichi Mori
Shizuo Kaji
Akira Matsuda
ResearchOpen Access07 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity

STING–type-I interferon pathway regulates the immunogenicity of several cancer types, including head and neck squamous cell carcinoma. Here the authors describe that glutamine metabolism in the tumour microenvironment dampens the STING–type-I interferon pathway by epigenetically silencing the expression of BATF2, which functions as a tumour suppressor.

Wang Gong
Hülya F. Taner
Yu Leo Lei
ResearchOpen Access29 Dec 2025
Nature Communications

Volume: 17, P: 1-20
National genomic surveillance integrating standardized quantitative susceptibility testing clarifies antimicrobial resistance in Enterobacterales

Kayama et al. present a blueprint for a national genomic surveillance study that conducts genome sequencing of thousands of strains, integrates standardized quantitative antimicrobial susceptibility testing, and characterizes antimicrobial resistance determinants.

Shizuo Kayama
Koji Yahara
Motoyuki Sugai
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Dipole Moments of Poly(oxypropylene), Poly[(S)-oxy(1-isopropylethylene)] and Their Monomeric Model Compounds

Tsuneo Hirano
Pham Huu Khanh
Shizuo Kitahara
Research01 Nov 1979
Polymer Journal

Volume: 11, P: 905-907
The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis

Current animal models of periodontitis are biased towards sample collection from gingival tissue, while other periodontal structures may play similarly important role in the initiation and maintenance of inflammation. Here authors present a model that enables a more comprehensive and longitudinal assessment of periodontal tissues, which points to a pivotal role for the peri-root tissues and an IL-33/ST2 axis in the pathogenesis.

Anhao Liu
Mikihito Hayashi
Tomoki Nakashima
ResearchOpen Access28 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Functional V region formation during in vitro culture of a murine immature B precursor cell line

Haruo Sugiyama
Shizuo Akira
Tadamitsu Kishimoto
Research30 Jun 1983
Nature

Volume: 303, P: 812-815
Essential role of Stat6 in IL-4 signalling

Kiyoshi Takeda
Takashi Tanaka
Shizuo Akira
Research18 Apr 1996
Nature

Volume: 380, P: 627-630
Functional expression of a microinjected E^dα gene in C57BL/6 transgenic mice

Ken-ichi Yamamura
Hitoshi Kikutani
Tadamitsu Kishimoto
Research04 Jul 1985
Nature

Volume: 316, P: 67-69
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

In response to signals from afferent TRPV1⁺ C-fibers, STAT3-dependent upregulation of LCN2 in reactive astrocytes of the spinal dorsal horn amplifies itch signaling in multiple rodent models of atopic and contact dermatitis.

Miho Shiratori-Hayashi
Keisuke Koga
Makoto Tsuda
Research20 Jul 2015
Nature Medicine

Volume: 21, P: 927-931
Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

Akira Goto
Kazufumi Matsushita
Jean-Marc Reichhart
Amendments and Corrections01 Feb 2008
Nature Immunology

Volume: 9, P: 216
X-ray crystal structure of IRF-3 and its functional implications

Kiyohiro Takahasi
Nobuo N Suzuki
Fuyuhiko Inagaki
Research12 Oct 2003
Nature Structural & Molecular Biology

Volume: 10, P: 922-927
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hiroaki Hemmi
Tsuneyasu Kaisho
Shizuo Akira
Research22 Jan 2002
Nature Immunology

Volume: 3, P: 196-200
CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

Ningshu Liu
Noriko Ohnishi
Kevin B Bacon
Research25 May 2003
Nature Immunology

Volume: 4, P: 687-693
Toll-like receptors control activation of adaptive immune responses

Markus Schnare
Gregory M. Barton
Ruslan Medzhitov
Research04 Sept 2001
Nature Immunology

Volume: 2, P: 947-950
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Hideo Yasukawa
Masanobu Ohishi
Akihiko Yoshimura
Research18 May 2003
Nature Immunology

Volume: 4, P: 551-556
Essential role of MD-2 in LPS responsiveness and TLR4 distribution

Yoshinori Nagai
Sachiko Akashi
Kensuke Miyake
Research10 Jun 2002
Nature Immunology

Volume: 3, P: 667-672
Identification of an atypical monocyte and committed progenitor involved in fibrosis

An atypical monocyte with partial granulocyte characteristics is identified and shown to be critical for the development of fibrosis.

Takashi Satoh
Katsuhiro Nakagawa
Shizuo Akira
Research21 Dec 2016
Nature

Volume: 541, P: 96-101
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Jonathan C Kagan
Tian Su
Ruslan Medzhitov
Research24 Feb 2008
Nature Immunology

Volume: 9, P: 361-368
Correction: Corrigendum: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Takafumi Oka
Shungo Hikoso
Kinya Otsu
Amendments and Corrections19 Sept 2012
Nature

Volume: 490, P: 292
Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

Ken J Ishii
Cevayir Coban
Shizuo Akira
Amendments and Corrections01 Apr 2006
Nature Immunology

Volume: 7, P: 427
Erratum A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi
Osamu Takeuchi
Shizuo Akira
Amendments and Corrections01 Feb 2001
Nature

Volume: 409, P: 646
Addendum: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

Hendrik Poeck
Michael Bscheider
Jürgen Ruland
Amendments and Corrections18 Dec 2013
Nature Immunology

Volume: 15, P: 109
Erratum: Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

Wouter J de Jonge
Esmerij P van der Zanden
Guy E Boeckxstaens
Amendments and Corrections01 Sept 2005
Nature Immunology

Volume: 6, P: 954
Completion of the entire hepatitis C virus life cycle in genetically humanized mice

The entire hepatitis C virus life cycle can be recapitulated in an inbred mouse model, allowing preclinical assessment of antiviral therapeutics and vaccines.

Marcus Dorner
Joshua A. Horwitz
Alexander Ploss
Research31 Jul 2013
Nature

Volume: 501, P: 237-241
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

The characteristics of the cell type(s) responsible for initiating protective gut immune responses are not fully defined. Akira and colleagues show that TLR5⁺ lamina propria dendritic cells trigger, in a retinoic-dependent way, the production of interleukin 17 and immunoglobulin A.

Satoshi Uematsu
Kosuke Fujimoto
Shizuo Akira
Research30 May 2008
Nature Immunology

Volume: 9, P: 769-776
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

In vitro studies suggest that the adaptor TANK is needed for the production of type 1 interferon. Using TANK-deficient mice, Akira and colleagues instead find that TANK negatively regulates Toll-like receptor and B cell antigen receptor signaling in vivo.

Tatsukata Kawagoe
Osamu Takeuchi
Shizuo Akira
Research09 Aug 2009
Nature Immunology

Volume: 10, P: 965-972
Nucleic acid sensing by T cells initiates Th2 cell differentiation

Nucleic acids modulate T cell responses; however, the physiological significance of this property remains unclear. Here, the authors show that self-DNA complexes with antimicrobial peptides or histones, which mediates T cell costimulation to induce Th2 cell differentiation.

Takayuki Imanishi
Chitose Ishihara
Takashi Saito
Research10 Apr 2014
Nature Communications

Volume: 5, P: 1-12
Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

Akira Goto
Kazufumi Matsushita
Jean-Marc Reichhart
Research09 Dec 2007
Nature Immunology

Volume: 9, P: 97-104
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Much is known about the activation of the NLRP3 inflammasome; however, the control of its physical assembly is less well understood. Akira and colleagues demonstrate that acetylated tubulin drives assembly of the inflammasome at mitochondria.

Takuma Misawa
Michihiro Takahama
Shizuo Akira
Research17 Mar 2013
Nature Immunology

Volume: 14, P: 454-460
Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension

Jiegen Chen
Josepmaria Argemi
Ramon Bataller
ResearchOpen Access23 Sept 2020
Scientific Reports

Volume: 10, P: 1-12
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

The production of chemoattractants in the pre-metastatic lung can be induced by distant primary tumours. The chemoattractants S100A8 and S100A9 induce serum amyloid A3 and TLR4 activation and cause an inflammation-like state that facilitates metastasis.

Sachie Hiratsuka
Akira Watanabe
Yoshiro Maru
Research28 Sept 2008
Nature Cell Biology

Volume: 10, P: 1349-1355
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.

Hidenori Iwasaki
Osamu Takeuchi
Shizuo Akira
Research30 Oct 2011
Nature Immunology

Volume: 12, P: 1167-1175
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Macrophages can be divided into two subsets, M1 and M2, which have crucial differences in their function. Akira and colleagues identify the histone demethylase Jmjd3 as a key factor in M2 development.

Takashi Satoh
Osamu Takeuchi
Shizuo Akira
Research22 Aug 2010
Nature Immunology

Volume: 11, P: 936-944
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Masahiro Yamamoto
Shintaro Sato
Shizuo Akira
Research21 Nov 2002
Nature

Volume: 420, P: 324-329
RIG-I-like antiviral protein in flies

The function of gene expression in the response of drosophila to viral infection is poorly understood. A report now demonstrates that the helicase Dicer-2 controls antiviral gene expression in addition to RNA interference–mediated gene silencing.

Osamu Takeuchi
Shizuo Akira
News & Views01 Dec 2008
Nature Immunology

Volume: 9, P: 1327-1328
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Thirumala-Devi Kanneganti
Nesrin Özören
Gabriel Núñez
Research11 Jan 2006
Nature

Volume: 440, P: 233-236
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Mitochondrial DNA escaping from the autophagy pathway can trigger inflammation through Toll-like receptor (TLR) 9, leading to abnormalities in cardiac structure and function, and increased mortality.

Takafumi Oka
Shungo Hikoso
Kinya Otsu
Research25 Apr 2012
Nature

Volume: 485, P: 251-255
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Fumitaka Hayashi
Kelly D. Smith
Alan Aderem
Research26 Apr 2001
Nature

Volume: 410, P: 1099-1103
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

Masahiro Yamamoto
Soh Yamazaki
Shizuo Akira
Research08 Jul 2004
Nature

Volume: 430, P: 218-222
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9

Katsuaki Hoshino
Takahiro Sugiyama
Tsuneyasu Kaisho
Research13 Apr 2006
Nature

Volume: 440, P: 949-953
Structure and function of a new STAT-induced STAT inhibitor

Tetsuji Naka
Masashi Narazaki
Tadamitsu Kishimoto
Research26 Jun 1997
Nature

Volume: 387, P: 924-929
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities. This activation is known to be mediated by transmembrane Toll-like receptors and cytosolic receptors; however, it remains unclear whether a mechanism exists that integrates these two nucleic-acid-sensing systems. High-mobility group box (HMGB) proteins 1, 2 and 3 are now shown to function as universal sentinels for nucleic-acid-mediated innate immune responses.

Hideyuki Yanai
Tatsuma Ban
Tadatsugu Taniguchi
Research05 Nov 2009
Nature

Volume: 462, P: 99-103
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Trude H. Flo
Kelly D. Smith
Alan Aderem
Research07 Nov 2004
Nature

Volume: 432, P: 917-921
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Hiroki Kato
Osamu Takeuchi
Shizuo Akira
Research09 Apr 2006
Nature

Volume: 441, P: 101-105
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

The cytoplasmic receptor RIG-I recognizes viral RNAs and initiates a protective innate immune response against a number of important viruses. Here, it is shown that RIG-I is regulated by ubiquitination.

Michaela U. Gack
Young C. Shin
Jae U. Jung
Research28 Mar 2007
Nature

Volume: 446, P: 916-920
A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi
Osamu Takeuchi
Shizuo Akira
Research07 Dec 2000
Nature

Volume: 408, P: 740-745
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

DNA vaccines induce adaptive immune responses mainly via induction of type-I interferon. This paper shows that this occurs by a mechanism that is independent of the activation of nucleic acid binding Toll-like receptors. B and CD4⁺ T cell responses require activation of the TBK pathway in hematopoietic cells, whereas TBK1 in non-hematopoietic cells is critical for the activation of CD8⁺ T cells.

Ken J. Ishii
Tatsukata Kawagoe
Shizuo Akira
Research07 Feb 2008
Nature

Volume: 451, P: 725-729
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

Mathias Heikenwalder
Magdalini Polymenidou
Adriano Aguzzi
Research25 Jan 2004
Nature Medicine

Volume: 10, P: 187-192
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chun-Jen Chen
Hajime Kono
Kenneth L Rock
Research17 Jun 2007
Nature Medicine

Volume: 13, P: 851-856
Toll-like receptors: critical proteins linking innate and acquired immunity

Shizuo Akira
Kiyoshi Takeda
Tsuneyasu Kaisho
Reviews01 Aug 2001
Nature Immunology

Volume: 2, P: 675-680

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