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Showing 1–14 of 14 results
Advanced filters: Author: Shotaro Nishitsuji Clear advanced filters

  • Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

    • Qingbo S. Wang
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

    • Ho Namkoong
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature
    Volume: 609, P: 754-760

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

    • Ryuya Edahiro
    • Go Sato
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1905-1921

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

    • Ryuya Edahiro
    • Yuya Shirai
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 753-767

  • Low-modulus polypropylene (LMPP) with controlled stereoregularity showed elastic recovery. To understand the underlying mechanism, changes in the morphology of LMPP under cyclic uniaxial elongation were investigated using in situ SAXS and WAXD. During the first cycle, the undulating structure of the crystal lamellae is large, and fragmentation of the lamellae occurs. On the other hand, during the second cycle, the little fragmentation of the lamellae occurs and that only the lamellae were rotating under elongation. Based on these results, lamella fragmentation has a significant effect on the elastic-recovery rate.

    • Shotaro Nishitsuji
    • Yuki Watanabe
    • Mikihito Takenaka
    Research
    Polymer Journal
    Volume: 52, P: 279-287

  • For atomically precise nanoparticle synthesis, it is crucial to understand hierarchical interactions during nanostructure formation. Here, the authors observe the crystal seed formation and simultaneous nanocrystal aggregation of ceria from aqueous solution in real time to understand hierarchically different intra- and interparticle interactions governing the particle shapes.

    • Noboru Aoyagi
    • Ryuhei Motokawa
    • Atsushi Ikeda-Ohno
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-13

  • To functionalize a poly(isosorbide carbonate) (PIC)-based polymer and evaluate its recyclability, several types of diol comonomers were copolymerized with isosorbide. The thermal and mechanical properties and decomposition behavior of the PIC copolymers were investigated. The thermal stability of PIC was retained, and its glass transition temperature was systematically controlled by copolymerization. The decomposition of the PIC copolymers upon treatment with aqueous ammonia yielded monomers and urea, and the decomposition rate was governed by the structure of the comonomer.

    • Kazuaki Rikiyama
    • Akari Matsunami
    • Daisuke Aoki
    Research
    Polymer Journal
    Volume: 56, P: 443-453

  • Self-organization in nonequilibrium systems composed of a bulk filler powder and a bulk polymer melt as an initial state (i) into a final ordered state (f) in applied mechanical field occurs via cascade evolution of the dissipative structures (a) to (e) accompanied by the cascade energy dissipation processes [Process (I) and Process (II)]. These processes also induce the relevant cascade changes in free energy and stress level.

    • Takeji Hashimoto
    • Naoya Amino
    • Mikihito Takenaka
    Reviews
    Polymer Journal
    Volume: 51, P: 109-130