Wnt/β-catenin signalling can regulate both self-renewal and differentiation of pluripotent stem cells. Here Kim et al.show that transcriptional regulation by nuclear β-catenin induces the differentiation of mouse epiblast stem cells and human embryonic stem cells, whereas cytoplasmic β-catenin supports their self-renewal.
- Hoon Kim
- Jun Wu
- Qi-Long Ying
