While hydrocarboxylation of acrylates with CO2 has been extensively explored, acrylamides remain under-investigated due to their lower electron cloud density. Here, the authors present an electrochemical method for selective hydrocarboxylation of acrylamides, achieving α- and β-carboxylation under mild conditions with high regioselectivity and broad substrate scope.
- Xiuli Zhao
- Ziren Chen
- Chenjiang Liu
