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Scientific Reports (4)
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Showing 1–12 of 12 results

Advanced filters: Author: Shu-Xia Zhang Clear advanced filters

Tailoring Cas12a functionality with a user-friendly and versatile crRNA variant toolbox

Flexible regulation of Cas12a activity enhances its performance across contexts. Here, authors achieve this with a simple crRNA direct repeat mutation strategy, improving Cas12a utility in gene editing and nucleic acid diagnostics.

Jing Han
Yuan Min
Han-Qing Yu
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-15
siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats

Yan-ping Zhang
Wen-bin Li
Min Zhang
Research04 Jun 2012
Acta Pharmacologica Sinica

Volume: 33, P: 897-908
Association between triglyceride glucose index-related indices with gallbladder disease: a prospective cohort study in rural China

Minghan Zhang
Jiang Sun
Xinyu Peng
ResearchOpen Access19 Nov 2025
Scientific Reports

Volume: 15, P: 1-9
Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection

CRISPR-based detection has long been challenged by the separation of amplification and detection steps. In this study, Cheng et al., show that heparin sodium modulates Cas12 cleavage activity and apply a one pot system to detect clinical influenza A virus and SARS-CoV-2 in wastewater.

Zhou-Hua Cheng
Xi-Yan Luo
Han-Qing Yu
ResearchOpen Access30 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Visceral Adiposity and Anthropometric Indicators as Screening Tools of Metabolic Syndrome among Low Income Rural Adults in Xinjiang

Shu-xia Guo
Xiang-hui Zhang
Yu-song Ding
ResearchOpen Access26 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Fabricating polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration

It is of great significance to exert the synergistic effect between single atom and support. Here, the authors prepare polyoxometalates-stabilized single-atom site catalysts in confined space with enhanced activity for alkynes diboration.

Yiwei Liu
Xi Wu
Yadong Li
ResearchOpen Access09 Jul 2021
Nature Communications

Volume: 12, P: 1-9
Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

Jun-Ming Zhu
Ke-Xin Li
Xiao-Ming Li
ResearchOpen Access10 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

In mouse models, the authors find that NRG1–ErbB4 signaling contributes to epilepsy through regulating the excitability of fast-spiking parvalbumin interneurons. ErbB4 expression was also reduced in human epileptogenic tissue.

Ke-Xin Li
Ying-Mei Lu
Xiao-Ming Li
Research11 Dec 2011
Nature Neuroscience

Volume: 15, P: 267-273
Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats

Yue Chen
Kang-xi Zhang
Guo-ping Zhao
ResearchOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1-12
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability

Xiao-ling Zhang
Wei-hong Du
Xin-chun Jin
Research20 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2241-2252
Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice

Ye-ru Chen
Shu-xia Zhang
Gang Chen
Research16 May 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2828-2840
Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus

Ying Zhang
Shu-Xia Cao
Xiao-Ming Li
Research22 Apr 2016
Cell Research

Volume: 26, P: 728-742