Cell migration is regulated by spatial and temporal information, but how the two are integrated is not well understood. Here, Nakajima et al. use dynamic microfluidics gradients to show that Ras activation at the leading edge of Dictyosteliumis suppressed when chemoattractant concentration decreases over time.
- Akihiko Nakajima
- Shuji Ishihara
- Satoshi Sawai
