Many spatial RNA monitoring assays can be hindered by barriers that limit short-transcript detection and mask cellular diversity. Here, the authors show TDDN-FISH – Tetrahedral DNA Dendritic Nanostructure–enhanced Fluorescence In Situ Hybridization. This is a rapid, enzyme-free method that uses self-assembling DNA nanostructures, thus accelerating RNA detection.
- Yi-Fan Wang
- Hua-Jie Chen
- Shu-Lin Liu
