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Showing 1–4 of 4 results

Advanced filters: Author: Shuo-Xing Dou Clear advanced filters

Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.

Tanlin Wei
Xiaofeng Yang
Hui Li
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 17, P: 1-12
Single-molecule reconstruction of eukaryotic factor-dependent transcription termination

Here, the authors report the kinetics of Sen1/RNA simultaneous release, Sen1-Pol II complex dissociation, and Pol II diffusion during eukaryotic Sen1-dependent transcription termination through single-molecule fluorescence assays.

Ying Xiong
Weijing Han
Ming Li
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-12
Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion

How do cells regulate their migration speed and direction? Here, authors discover that keratocyte cells can reversibly switch between different migration modes, by changing the 3D lamellipodium shape and intracellular diffusion.

Chao Jiang
Hong-Yu Luo
Hui Li
ResearchOpen Access24 Aug 2023
Nature Communications

Volume: 14, P: 1-13
Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding

Wen-Qiang Wu
Xi-Miao Hou
Xu-Guang Xi
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-11