Superoxide dismutase (SOD) is an enzyme that eliminates reactive oxygen species and is used in the treatment of oxidative stress-related diseases, but its catalytic activity is constrained by the metal ion coordination with rigid amino-acid residues. Here, the authors report Cu/Zn/histidine supramolecular assemblies with optimized Cu catalytic site and SOD activity up to 37900 Unit/mg, which is at least 5.4 times higher than that of natural Cu-Zn-SOD.
- Hao Jin
- Xuanqi Zhu
- Hao Zhang
