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Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids

Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

Byung Ho Lee
Kana Fuji
Anne Grapin-Botton
ResearchOpen Access19 Dec 2025
Nature Cell Biology

Volume: 28, P: 113-124
Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function

Diabetes is characterized by loss or dysfunction of pancreatic β-cells. Here the authors show that the signalling protein WNT4 is heterogeneously activated by β-cells during their postnatal maturation with WNT4 positive cells being more mature, and that inactivating WNT4 in β-cells after maturation impairs beta-cell function.

Keiichi Katsumoto
Siham Yennek
Anne Grapin-Botton
ResearchOpen Access21 Oct 2022
Nature Communications

Volume: 13, P: 1-15
Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure

Epithelial organoids share a common central lumen with various shapes and dynamics. Here, authors show that epithelial cysts formed from three different cell types obey the same physical laws and end up with a single lumen following conserved rules depending on their luminal pressure.

Linjie Lu
Kana Fuji
Daniel Riveline
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Towards a better understanding of diabetes mellitus using organoid models

Organoid systems have great potential to improve the study of diseases such as diabetes mellitus. This Review assesses the progress in developing pancreatic organoids and bioengineered systems for modelling diabetes mellitus and its complications.

Belin Selcen Beydag-Tasöz
Siham Yennek
Anne Grapin-Botton
Reviews20 Jan 2023
Nature Reviews Endocrinology

Volume: 19, P: 232-248

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Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids

Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function

Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure

Towards a better understanding of diabetes mellitus using organoid models

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