Adipose tissue macrophage (ATM) has been implicated in inflammation and obesity, but the underlying mechanisms are still unclear. Here the authors show that AMPK is suppressed in ATMs from mice fed with high fat diet, leading to subsequent activation of SUCLA2, over-production of succinate and IL-1β, and ultimately inflammation and obesity.
- Chang Peng
- Haowen Jiang
- Jia Li
