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Roeck et al. show that ferroptosis spreads between neighboring cells via lipid peroxidation across adjacent membranes. Cell contact and extracellular iron are key factors, highlighting a potential mechanism for tissue necrosis propagation.

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

This study reports the characterization of a double white dwarf that will explode as a type Ia supernova on our Galactic doorstep. Given that the source is so close, this event would outshine all stars in the sky, with an apparent magnitude of −16.

The microvasculature is critical for delivery of oxygen and metabolites throughout tissues. Here they use human blood vessel organoids to show that CTGF is a critical paracrine regulator of microvascular integrity that can restore pericyte coverage and vessel structure.

Enhanced Classification of Localized Point clouds by Shape Extraction (ECLiPSE) is a robust feature extraction and classification pipeline for diverse and heterogeneous structures in both 2D and 3D single-molecule localization microscopy data.

SKP2 is an oncogenic E3-ubiquitin ligase. Here the authors show that SKP2 is epigenetically regulated by the muscle lineage transcription factor MYOD, supports tumorigenesis in the Fusion Negative (FN) subtype of rhabdomyosarcoma (RMS) and impairs differentiation promoting degradation of p57^Kip2.

In June 2022, the IXPE satellite observed a shock passing through the jet of active galaxy Markarian 421. The rotation of the X-ray-polarized radiation over a 5-day period revealed that the jet contains a helical magnetic field.

Lymphocytes are on high demand during chronic infections. Here, the authors show that human lymphoid precursors, normally found in the bone marrow, circulate in the blood of chronic inflammation patients and give rise to natural killer cells and other lymphocytes.

TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the anterior cingulate cortex, TRPV1 is functionally expressed in microglia; stimulation of TRPV1 activates microglia, which in turn affects glutamatergic neurotransmission.

Prion protein has been suggested to bind toxic amyloid-ß oligomers. Nicollet al.demonstrate that binding to prion protein and prion protein-dependent synaptotoxicity correlate with the presence of a tubular form of amyloid-ß with a defined triple helical structure.

The rare blood group Dantu is known to protect against severe malaria, and a mechanism is proposed here: Dantu red blood cells have a high membrane tension that prevents invasion by malaria parasites.

In a mouse model of Alzheimer's disease, the authors find that early loss of AMPA receptors at synapses at onset of cognitive dysfunction is a result of activation of the phosphatase calcineurin by caspase-3. Inhibition of caspase activity rescued both synapse density and fear memory in this model.

Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail.

Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..

Polarization measurements are reported for the blazar Mk501, revealing a degree of X-ray polarization that is more than twice the optical value and supporting the shock-accelerated energy-stratified electron population scenario.

Single-cell transcriptomic analysis of human multipotent progenitor cells reveals that upon adipogenic stimulation, Wnt signaling regulates the generation of functional multipotent mesenchymal progenitors, named structural Wnt-regulated adipose tissue resident cells, which maintain the progenitor pool.

Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs from human embryos and pluripotent stem cell cultures.

The motor protein myosin II is implicated in three-dimensional organ development. In this study, the authors apply live imaging techniques to describe the dynamics of the developing Drosophilawing and the involvement of myosin II in this process.

Little is known about Mesozoic marine reptile dead-falls. Here, the authors reconstruct the ecological succession of a Late Jurassic shallow-water ichthyosaur fall community and show that it fulfilled ecological roles similar to shallow whale falls and did not support specialized chemosynthetic communities.

Primary lymphoedema can lead to the swelling of the extremities and facial dysmorphism. Here the authors present evidence that compound heterozygous and homozygous mutations inPIEZO1result in an autosomal recessive form of generalised lymphatic dysplasia.

Cyclodipeptide oxidases are filamentous enzymes. Here, the authors dissect the mechanism of a promiscuous flavoenzyme from the biosynthesis of cyclodipeptide natural products, unveiling fast catalysis for peptide oxidation in a distinct active site.

Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca²⁺-permeable ion channel that plays a pivotal role in the peripheral and central nervous systems; however, the effect of cellular redox state on the TRPM3 activity is unknown. Here, the authors reveal that TRPM3 channel activity is bidirectionally modulated by oxidizing and reducing agents, and identify cysteine residues in the extracellular pore loop of TRPM3 that carry the redox-control of the channel.

Chirality transfer across length-scales is an intriguing phenomenon but connecting the properties of individual building blocks to the emergent features of their resulting large-scale structure remains challenging. Here, the authors investigate the origins of mesophase chirality in cellulose nanocrystal suspensions, whose self-assembly into chiral photonic films has attracted significant interest.

Two-pore channels (TPCs) are cation channels that localize to acidic organelles to regulate Ca²⁺ dependent events. Here, Li et al. characterize a TPC from Toxoplasma gondii(TgTPC) that localizes to the apicoplast, is critical for maintaining its integrity and relevant for Ca²⁺ uptake from the ER through stabilizing inter-organelle contact.

Multiple complementary optical signatures confirm the persistence of ferroelectricity and inversion-symmetry-breaking magnetic order down to monolayer NiI₂, introducing the physics of type-II multiferroics into the area of van der Waals materials.

Ferroelectrics are electro-active materials that can store and switch their polarity, sense temperature changes, interchange electric and mechanical functions, and manipulate light. Subtle changes in the topology of certain chemical bonds have long been identified as a possible route for achieving ferroelectricity in organic molecular crystals. Ferroelectricity above room temperature is now demonstrated by applying an electric field to coherently align the molecular polarities in crystalline croconic acid.

A nematode symbiont Robbea hypermnestra divides longitudinally and asynchronously in a host-oriented fashion.

Folgueira et al. show that dopamine signalling in the lateral hypothalamic area and the zona incerta reduces body weight and increases energy expenditure by increasing brown adipose tissue thermogenesis in rodents. Weight loss and increased energy expenditure were also observed in patients treated with a dopamine receptor 2 agonist.

There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals

Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector function of immune-responsive platelets

The mechanism of cytokinetic failure in the migrating zebrafish epicardium leading to multinucleated cells is shown to be driven by the interaction of the cytokinetic ring and the extracellular matrix through adhesion reinforcement by high traction forces.

The fate of ocean carbon is determined by the balance between primary productivity and heterotrophic breakdown of that photosynthate. Here the authors show that diatoms produce a polysaccharide that resists bacterial degradation, accumulates, aggregates and stores carbon during spring blooms.

Analysis of plastic debris found in surface waters shows that lakes and reservoirs in densely populated and urbanized regions, as well as those with elevated deposition areas, are particularly vulnerable to plastic contamination.

Inhibition of S6 kinase 1 (S6K1) extends lifespan in mice, but the underlying mechanisms are not fully understood. Here Gallage et al. show that reduction of S6K signaling diminishes inflammation in the aged mouse liver via suppression of the senescence-associated secretory phenotype.

CDK12 is a therapeutic target and cancer gene required for genome integrity. Here, the Authors show that loss or inhibition of CDK12 leads to persistent transcription of damaged genes, and triggers transcription replication conflicts leading to selective cell death in Myc- driven tumors.

During female gametogenesis in plants, the Megaspore Mother Cell (MMC) accumulates β−1,3-glucan. Here Pinto et al. show that increased β−1,3-glucanase in the MMC delays β−1,3-glucan deposition, disrupts cell identity, and halts gametogenesis.

Reproduction in mammals is dependent on the function of specific neurons that secrete gonadotropin-releasing hormone (GnRH) and project their axons to the median eminence (ME) of the hypothalamus. Here the authors show that Semaphorin7A signaling plays a role in mediating the plasticity of GnRH axon terminals and tanycytes in the ME.

The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle transport, and that loss of VAMP7 leads to reduced cold avoidance in vivo.

After expression of the PML–RAR oncogene in haematopoietic stem cells, p21 is necessary to limit cell cycle progression and thus limit the accumulation of DNA damage which would otherwise limit the self-renewal of leukaemic stem cells and prevent the development of leukaemia

Synthetic organic fluorophores are powerful tools for bioimaging, but frequently display shortened observation times and signal fluctuations. Here, the authors report a general method to covalently label a biomolecule with a fluorophore and photostabilizer, reducing unwanted photophysical effects by intramolecular quenching of reactive fluorophore states.

Patients with oesophageal diseases may require surgical removal and replacement of the oesophagus. Here the authors seed mesenchymal stromal cells on a decellularized rat oesophagus and show that this bioengineered tissue construct restores swallowing function after transplantation into rats.

Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease.

The roles of Coronin, Cofilin and AIP1 in promoting actin disassembly have not been well understood. Here using single-molecule fluorescence imaging, Jansen et al. show that the three proteins act together in a coordinated, temporal pathway to induce rapid severing and disassembly of actin filaments.