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Showing 1–3 of 3 results

Advanced filters: Author: Silvia Zampar Clear advanced filters

4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy

This study shows that high-molecular weight tau has enhanced seeding capacity, and seeding differences can define molecular subtypes of progressive supranuclear palsy, underpinning the disease’s heterogeneity.

Ivan Martinez-Valbuena
Seojin Lee
Gabor G. Kovacs
ResearchOpen Access31 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease.

Constanze Depp
Ting Sun
Klaus-Armin Nave
ResearchOpen Access31 May 2023
Nature

Volume: 618, P: 349-357
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.

Matthias Kettwig
Katharina Ternka
Jutta Gärtner
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-18