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Showing 1–4 of 4 results
Advanced filters: Author: Simon Lindhoud Clear advanced filters

  • BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

    • Martin Pacesa
    • Lennart Nickel
    • Bruno E. Correia
    ResearchOpen Access
    Nature
    Volume: 646, P: 483-492

  • Auxin is a universal regulator of plant growth and development. The authors report the origin and evolutionary history of the key DNA-binding transcription factors mediating auxin response, identifying key steps in the birth of auxin response.

    • Jorge Hernández-García
    • Vanessa Polet Carrillo-Carrasco
    • Dolf Weijers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Flavodoxin requires tight binding of its FMN cofactor to be active, but the residues involved are unknown. In this biophysical study, FMN binding is shown to change from nanomolar to picomolar affinity on extremely slow protein relaxation and the residues responsible for cofactor binding are identified.

    • Yves J.M. Bollen
    • Adrie H. Westphal
    • Carlo P.M. van Mierlo
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-9

  • The minimal regulatory logic and the evolutionary history of the auxin signalling pathway are explored by studying the much simpler auxin network in Marchantia with a combination of genetic, domain shuffling and biochemical strategies.

    • Hirotaka Kato
    • Sumanth K. Mutte
    • Dolf Weijers
    Research
    Nature Plants
    Volume: 6, P: 473-482