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Advanced filters: Author: Simona Kavrokova Clear advanced filters

  • Locally elevated cholesterol in colorectal cancer cells with adenomatous polyposis coli truncation was observed to drive Wnt–β-catenin signaling through Dishevelled (Dvl). Inhibitors targeting the cholesterol–Dvl interaction potently suppress tumor growth without adverse side effects.

    • Ashutosh Sharma
    • Julian Zalejski
    • Wonhwa Cho
    Research
    Nature Chemical Biology
    Volume: 21, P: 1376-1386