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Showing 1–3 of 3 results
Advanced filters: Author: Simone Marsili Clear advanced filters

  • JNJ-9676—a small-molecule inhibitor targeting coronavirus M protein that shows excellent efficacy in Syrian golden hamster models—binds to and stabilizes the M protein dimer in an altered conformational state between its long and short forms, preventing the release of infectious virus.

    • Ellen Van Damme
    • Pravien Abeywickrema
    • Marnix Van Loock
    ResearchOpen Access
    Nature
    Volume: 640, P: 506-513

  • Structural insights into SARS and MERS coronavirus membrane protein reveals differences and conserved sites of an inhibitor binding pocket, aiding in the design of broad-spectrum and specific antivirals.

    • Mandeep Kaur Mann
    • Yanting Yin
    • Pravien Abeywickrema
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-10