Acetylation of histone lysine residues correlates with transcription activation, but it is currently debated whether histone acetylation is a cause or a consequence of transcription. Here, the authors show how global protein acetylation remains unaltered after acute inhibition of transcription, indicating that histone acetylation is not merely a consequence of transcription.
- Tim Liebner
- Sinan Kilic
- Chunaram Choudhary