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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.

Edgar Gonzalez-Kozlova
Robert Sweeney
Sacha Gnjatic
ResearchOpen Access27 Jan 2026
Nature Medicine

P: 1-14
Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline

A scalable pipeline MARQO resolves the multiparametric cellular and spatial data in responders to immune checkpoint blockade therapy relative to non-responders.

Mark Buckup
Igor Figueiredo
Sacha Gnjatic
ResearchOpen Access25 Aug 2025
Nature Biomedical Engineering

P: 1-15

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Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Multiparametric cellular and spatial organization in cancer tissue lesions with a streamlined pipeline

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