Nature Search

Computational modeling enables individual assessment of postprandial glucose and insulin responses after bariatric surgery

Poyraz, Heinonen et al. model the individual postprandial glucose and insulin responses in people with obesity who underwent either Roux-en-Y gastric bypass or One-Anastomosis gastric bypass surgery. They find differences in postprandial glucose and insulin responses related to the surgery method used.

Onur Poyraz
Sini Heinonen
Kirsi H. Pietiläinen
ResearchOpen Access23 Oct 2025
Communications Medicine

Volume: 5, P: 1-11
Distinct fasting and postprandial bile acid responses following Roux-en-Y and one-anastomosis gastric bypass

Matti Jänis
Tuure Saarinen
Sini Heinonen
ResearchOpen Access05 Jan 2026
International Journal of Obesity

P: 1-10
Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial

S. Heinonen
J. E. Karppinen
K. H. Pietiläinen
ResearchOpen Access06 Jan 2026
International Journal of Obesity

P: 1-12
The effect of obesity and aging on NAD⁺/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI

Helena A. K. Lapatto
Birgitta W. van der Kolk
Kirsi H. Pietiläinen
ResearchOpen Access05 Jan 2026
International Journal of Obesity

P: 1-9
Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue

This multiomic study, including single-nucleus DNA methylation and chromatin conformation matched with single-nuclei RNA sequencing, provides insights into the epigenomic landscape of human subcutaneous adipose tissue.

Zeyuan Johnson Chen
Sankha Subhra Das
Päivi Pajukanta
ResearchOpen Access20 Aug 2025
Nature Genetics

Volume: 57, P: 2238-2249
Author Correction: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

Camilla Bean
Matteo Audano
Luca Scorrano
Amendments and Corrections11 Feb 2022
Nature Metabolism

Volume: 4, P: 300
Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

In obesity, mitochondrial communication with the nucleus may be disrupted. Here, the authors use Finnish twin data to link obesity-related changes in mitochondrial DNA quantity with the methylation and expression of SH3BP4 in adipose tissue.

Aino Heikkinen
Vivienne F. C. Esser
Miina Ollikainen
ResearchOpen Access12 May 2025
Nature Communications

Volume: 16, P: 1-14
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites

Bean et al. provide evidence showing that the mitochondrial cristae biogenesis protein Opa1 facilitates cell-autonomous white to brown/beige adipocyte conversion, through a process dependent on the urea cycle.

Camilla Bean
Matteo Audano
Luca Scorrano
Research06 Dec 2021
Nature Metabolism

Volume: 3, P: 1633-1647
High diversity of cultivable heterotrophic bacteria in association with cyanobacterial water blooms

Katri A Berg
Christina Lyra
Jarkko Rapala
Research20 Nov 2008
The ISME Journal

Volume: 3, P: 314-325

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