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Showing 1–19 of 19 results
Advanced filters: Author: Sirio Dupont Clear advanced filters

  • Forces transmitted through cell–cell and cell–extracellular matrix adhesions control cell fate decisions. But how are mechanical cues translated into gene expression programmes? The transcriptional regulators YAP and TAZ have arisen as convergence points of mechanical and biochemical signals.

    • Georg Halder
    • Sirio Dupont
    • Stefano Piccolo
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 591-600

  • Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix viscoelastic cues, through a coordinated interaction with molecular clutch mechanisms.

    • Mariana A. G. Oliva
    • Giuseppe Ciccone
    • Manuel Salmeron-Sanchez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Romani et al. report that cells on soft extracellular matrix have increased mitochondrial fission, with subsequent production of mitochondrial reactive oxygen species and NRF2, which may increase resistance to reactive oxygen species-dependent chemotherapy drugs in breast cancer cells in vitro and in mouse lungs.

    • Patrizia Romani
    • Nunzia Nirchio
    • Sirio Dupont
    Research
    Nature Cell Biology
    Volume: 24, P: 168-180

  • Dupont and Wickström review the current understanding of how mechanical forces regulate chromatin state and gene expression and discuss the importance of this mechanosensitive gene regulation to physiology and disease.

    • Sirio Dupont
    • Sara A. Wickström
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 624-643

  • Generation of the organizer tissue is induced on the dorsal side of the developing embryo by an asymmetry in Nodal signalling, which is only sufficiently high dorsally to induce organizer-specific gene expression. Now, through the identification of a microRNA (miR-15 and miR-16) that targets the Nodal receptor, microRNA is shown to have a role in this process.

    • Graziano Martello
    • Luca Zacchigna
    • Stefano Piccolo
    Research
    Nature
    Volume: 449, P: 183-188

  • Del Sal and colleagues demonstrate that the YAP and TAZ effectors of the Hippo pathway are under the control of the mevalonate pathway. They show that mutant p53 and SREBP-dependent activation of mevalonate signalling activates YAP and TAZ and promotes tumour formation in mice, a growth phenotype also conserved in Drosophila.

    • Giovanni Sorrentino
    • Naomi Ruggeri
    • Giannino Del Sal
    Research
    Nature Cell Biology
    Volume: 16, P: 357-366

  • Marco Sandri, Helge Amthor, Stefano Piccolo and colleagues show that BMP signaling is a key positive regulator of muscle hypertrophy. They further show that inhibiting BMP signaling causes muscle atrophy, abolishes the hypertrophic phenotype of myostatin knockout mice and exacerbates the effects of denervation and fasting.

    • Roberta Sartori
    • Elija Schirwis
    • Marco Sandri
    Research
    Nature Genetics
    Volume: 45, P: 1309-1318

  • Mechanical forces are important regulators of cell function and behaviour. This role is partly achieved through the modulation of cell metabolism, which, reciprocally, affects tissue mechanics. Unravelling the mechanisms of this crosstalk will increase our understanding of how cells interact with their microenvironment.

    • Patrizia Romani
    • Lorea Valcarcel-Jimenez
    • Sirio Dupont
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 22-38

  • Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.

    • Arianna Pocaterra
    • Gloria Scattolin
    • Sirio Dupont
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13

  • In the TGFβ pathway, receptor-activated SMADs (R-SMADs) associate with SMAD4 to regulate transcription. Piccolo and colleagues reveal that the deubiquitylase USP15 is required for TGFβ responses by reversing R-SMAD ubiquitylation and thereby promoting the retention of the SMAD complex at promoters.

    • Masafumi Inui
    • Andrea Manfrin
    • Stefano Piccolo
    Research
    Nature Cell Biology
    Volume: 13, P: 1368-1375

  • This paper shows that microfluidic perfusion frequency can be optimized to improve the differentiation of human pluripotent stem cells along different lineages, and uses this principle to achieve functional hPSC differentiation directly on a chip.

    • Giovanni G Giobbe
    • Federica Michielin
    • Nicola Elvassore
    Research
    Nature Methods
    Volume: 12, P: 637-640

  • Achondroplasia is the most common skeletal dysplasia and is characterized by various lifelong clinical, functional and psychosocial challenges for affected individuals. This first International Consensus Statement on the care of children and adults with achondroplasia aims to facilitate the global standardization and improvement of achondroplasia clinical care.

    • Ravi Savarirayan
    • Penny Ireland
    • Svein Otto Fredwall
    Reviews
    Nature Reviews Endocrinology
    Volume: 18, P: 173-189