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Viruses and cardiovascular disease: from bad to worse

Viral infections and cardiovascular disease (CVD) share a two-way connection: viral infection can raise CVD risk, and people with CVD are more prone to severe viral infection. Zhao et al. now detail a molecular mechanism whereby macrophages from patients with CVD inhibit antiviral T cell responses via immune checkpoint activation.

Siroon Bekkering
David Burgner
News & Views13 Jul 2022
Nature Cardiovascular Research

Volume: 1, P: 601-602
The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function

Julia van Tuijl
Debby Vreeken
Niels P. Riksen
Research20 Aug 2025
International Journal of Obesity

Volume: 49, P: 2473-2483
Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Maziar Divangahi
Peter Aaby
Mihai G. Netea
Amendments and Corrections20 May 2021
Nature Immunology

Volume: 22, P: 928
Trained immunity, tolerance, priming and differentiation: distinct immunological processes

The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.

Maziar Divangahi
Peter Aaby
Mihai G. Netea
Comments & Opinion08 Dec 2020
Nature Immunology

Volume: 22, P: 2-6
Trained immunity in atherosclerotic cardiovascular disease

In this Review, Riksen and colleagues discuss the molecular and cellular mechanisms of trained immunity, the activation of these mechanisms by cardiovascular risk factors, and how trained immunity might contribute to atherosclerosis and atherosclerotic cardiovascular disease. The authors also propose potential strategies for the therapeutic modulation of trained immunity in atherosclerotic cardiovascular disease.

Niels P. Riksen
Siroon Bekkering
Mihai G. Netea
Reviews15 Jun 2023
Nature Reviews Cardiology

Volume: 20, P: 799-811
Decreasing severity of obesity from early to late adolescence and young adulthood associates with longitudinal metabolomic changes implicated in lower cardiometabolic disease risk

Toby Mansell
Costan G. Magnussen
Christoph Saner
Research06 Jan 2022
International Journal of Obesity

Volume: 46, P: 646-654
Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

Maartje C. P. Cleophas
Jacqueline M. Ratter
Leo A. B. Joosten
ResearchOpen Access28 Jan 2019
Scientific Reports

Volume: 9, P: 1-10

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Viruses and cardiovascular disease: from bad to worse

The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Trained immunity in atherosclerotic cardiovascular disease

Decreasing severity of obesity from early to late adolescence and young adulthood associates with longitudinal metabolomic changes implicated in lower cardiometabolic disease risk

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

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