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Showing 1–6 of 6 results
Advanced filters: Author: Snehal N. Chaudhari Clear advanced filters

  • Levels of the endogenous bile acid cholic acid-7-sulfate (CA7S) increase in the gastrointestinal tract of both mice and humans after sleeve gastrectomy. CA7S acts through the G-protein-coupled receptor TGR5 to increase glucose tolerance during insulin resistance.

    • Snehal N. Chaudhari
    • David A. Harris
    • A. Sloan Devlin
    Research
    Nature Chemical Biology
    Volume: 17, P: 20-29

  • A covalent pan-inhibitor of bacterial bile salt hydrolases developed by adding a chenodeoxycholic acid moiety to the warhead is not bactericidal and is therefore useful for studying the effects of bile acids on host physiology.

    • Arijit A. Adhikari
    • Tom C. M. Seegar
    • A. Sloan Devlin
    Research
    Nature Chemical Biology
    Volume: 16, P: 318-326

  • Sulfated compounds produced collaboratively by the microbiome and the host have important biological functions. This Review highlights the production of select sulfated carbohydrates, amino acid derivatives and steroidal metabolites and discusses their influence on health. The Review also explore potential roles of sulfated molecules in disease detection, prevention and treatment.

    • Gabriel D. D’Agostino
    • Snehal N. Chaudhari
    • A. Sloan Devlin
    Reviews
    Nature Chemical Biology
    Volume: 20, P: 410-421

  • Mitochondria can undergo shape changes as a result of fusion and fission events. Here the authors describe how insulin signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necessary, but not sufficient, for longevity of worms with mutations that increase lifespan.

    • Snehal N. Chaudhari
    • Edward T. Kipreos
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • This Review article explores how uncovering phenotypes linked to the human microbiome often progresses from correlative studies to studies in germ-free animals and fecal microbiota transplants and, finally, to identification of strains and molecules.

    • Snehal N. Chaudhari
    • Megan D. McCurry
    • A. Sloan Devlin
    Reviews
    Nature Chemical Biology
    Volume: 17, P: 1046-1056