Here Ishikawa et al. determine the cryo-electron microscopy structures of the PspCas13b–guide RNA complex alone and in complex with target RNA, as well as that of the dPspCas13b–ADAR2–guide RNA–target RNA complex, thereby providing mechanistic insights into RNA cleavage and editing.
- Junichiro Ishikawa
- Kazuki Kato
- Hiroshi Nishimasu
