Nature Search

Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae

Soman N. Abraham
Daxi Sun
Edwin H. Beachey
Research15 Dec 1988
Nature

Volume: 336, P: 682-684
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

Ravi Malaviya
Teruo Ikeda
Soman N. Abraham
Research02 May 1996
Nature

Volume: 381, P: 77-80
Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice

Sepsis may progress into lethal septic shock, but the cellular mechanisms are still unclear. Here the authors show that, in septic mice, platelets activate perivascular mast cells to cause systemic hypotension and vascular pathology, while inhibiting platelets or mast cell activation suppresses septic shock induction, thereby implicating potential therapy targets.

Hae Woong Choi
Joo Hwan Noh
Jörn Karhausen
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

Soman Abraham and his colleagues report a new mechanism of immune suppression used by Salmonella. The bacteria traffic to lymph nodes, where Salmonella lipopolysaccharide triggers the downmodulation of certain chemokines, disrupting the cellular organization of the lymph node and impairing adaptive immunity.

Ashley L St John
Soman N Abraham
Research25 Oct 2009
Nature Medicine

Volume: 15, P: 1259-1265
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

Abderrazzaq Belaaouaj
Ronald McCarthy
Steven D. Shapiro
Research01 May 1998
Nature Medicine

Volume: 4, P: 615-618
Childhood eczema linked to mother’s stress during pregnancy

The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part.

Abhay P. S. Rathore
Soman N. Abraham
News & Views27 Aug 2025
Nature

Volume: 646, P: 39-40
Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components

Abraham and colleagues found that antigen-triggered degranulation in IgE-sensitized mast cells was mediated by the inflammasome components NLRP3 and ASC.

Andrea Mencarelli
Pradeep Bist
Soman N. Abraham
Research14 Mar 2024
Nature Immunology

Volume: 25, P: 693-702
A highly polarized T_H2 bladder response to infection promotes epithelial repair at the expense of preventing new infections

Abraham and colleagues show that a highly polarized T_H2 bladder response to urinary tract infections promotes epithelial repair at the expense of preventing new infections and associated bladder dysfunction.

Jianxuan Wu
Byron W. Hayes
Soman N. Abraham
Research18 May 2020
Nature Immunology

Volume: 21, P: 671-683
Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis

Although great progress has been made in the field of dengue research, there are still many unanswered questions concerning the interactions between dengue virus and the human immune system. In this Opinion article, Gubler and colleagues discuss the gaps in our understanding of the molecular pathogenesis of dengue virus and call for a reassessment of the animal models used in the preclinical stages of dengue research.

Ashley L. St. John
Soman N. Abraham
Duane J. Gubler
Reviews08 May 2013
Nature Reviews Microbiology

Volume: 11, P: 420-426
The nature of immune responses to urinary tract infections

This Review describes our current understanding of innate and adaptive immune responses in the urinary tract and how immunomodulatory therapies could provide benefit in an era of increasing antibiotic resistance among uropathogens.

Soman N. Abraham
Yuxuan Miao
Reviews21 Sept 2015
Nature Reviews Immunology

Volume: 15, P: 655-663
Mast cell-orchestrated immunity to pathogens

In this Review the authors describe the key attributes of mast cells that make them well suited to initiate and coordinate innate and adaptive immune responses to pathogens, by acting as pathogen sensors, immune effectors and immune modulators.

Soman N. Abraham
Ashley L. St. John
Reviews01 Jun 2010
Nature Reviews Immunology

Volume: 10, P: 440-452
Mast cell activators: a new class of highly effective vaccine adjuvants

James B McLachlan
Christopher P Shelburne
Soman N Abraham
Research20 Apr 2008
Nature Medicine

Volume: 14, P: 536-541
Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic

David M. Baorto
Zhimin Gao
Soman N. Abraham
Research09 Oct 1997
Nature

Volume: 389, P: 636-639
Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells

Brian L Bishop
Mathew J Duncan
Soman N Abraham
Research08 Apr 2007
Nature Medicine

Volume: 13, P: 625-630
Structure, function and pharmacology of human itch GPCRs

Structural studies of the itch receptors MRGPRX2 and MRGPRX4 in complex with endogenous and synthetic ligands provide a basis for the development of therapeutic compounds for pain, itch and mast cell-mediated hypersensitivity.

Can Cao
Hye Jin Kang
Bryan L. Roth
Research17 Nov 2021
Nature

Volume: 600, P: 170-175
Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

Mast cells act to enhance immune responses through the release of insoluble granules that contain inflammatory mediators. Now, submicrometre polymer particles are shown to replicate and enhance the functions of mast-cell granules in vivo, such as the targeting of draining lymph nodes and the timed release of encapsulated mediators. The particles can also polarize the resulting immune response.

Ashley L. St. John
Cheryl Y. Chan
Soman N. Abraham
Research22 Jan 2012
Nature Materials

Volume: 11, P: 250-257
Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

James B McLachlan
Justin P Hart
Soman N Abraham
Research02 Nov 2003
Nature Immunology

Volume: 4, P: 1199-1205
Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity

Immunization with inactivated Japanese encephalitis vaccine generates cross-reactive antibodies that enhance immunogenicity on subsequent immunization with live attenuated yellow fever vaccine, demonstrating antibody-dependent enhancement of infection in a clinical trial.

Kuan Rong Chan
Xiaohui Wang
Eng Eong Ooi
Research19 Sept 2016
Nature Microbiology

Volume: 1, P: 1-10
Mastoparan-7 adjuvanted COBRA H1 and H3 hemagglutinin influenza vaccines

Pedro L. Sanchez
Herman F. Staats
Ted M. Ross
ResearchOpen Access14 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy

Ashley L. St. John
Hae Woong Choi
Herman F. Staats
ResearchOpen Access05 Feb 2020
npj Vaccines

Volume: 5, P: 1-9
Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection

Ased S. M. Ali
Catherine Mowbray
Judith Hall
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-14

Search

Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice

Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

Childhood eczema linked to mother’s stress during pregnancy

Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components

A highly polarized T_H2 bladder response to infection promotes epithelial repair at the expense of preventing new infections

Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis

The nature of immune responses to urinary tract infections

Mast cell-orchestrated immunity to pathogens

Mast cell activators: a new class of highly effective vaccine adjuvants

Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic

Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells

Structure, function and pharmacology of human itch GPCRs

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

Cross-reactive antibodies enhance live attenuated virus infection for increased immunogenicity

Mastoparan-7 adjuvanted COBRA H1 and H3 hemagglutinin influenza vaccines

Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy

Targeting Deficiencies in the TLR5 Mediated Vaginal Response to Treat Female Recurrent Urinary Tract Infection

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