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Structural basis of drug recognition by human MATE1 transporter

Human MATE1 is a key transporter in kidney and liver drug clearance. Here, authors present cryo-EM structures of MATE1 in complex with substrates and an inhibitor, revealing the structural basis of drug recognition.

Ksenija Romane
Giulia Peteani
Kaspar P. Locher
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial

To address an evidence gap for the efficacy of hypertension therapy using dual drug combinations in patients of South Asian origin, a randomized clinical trial conducted in India found that three types of dual drug combinations, each administered in a single pill, had similarly large effects on reducing blood pressure.

Dorairaj Prabhakaran
Ambuj Roy
Neil R. Poulter
ResearchOpen Access25 Jul 2025
Nature Medicine

Volume: 31, P: 3169-3175
Structure of human drug transporters OATP1B1 and OATP1B3

A key step of drug metabolism in the human body is the uptake into liver cells, which is mediated by transport proteins of the OATP family. Here, authors report cryo-EM structures of two human OATP proteins, providing insight into their function.

Anca-Denise Ciută
Kamil Nosol
Kaspar P. Locher
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor

Different phosphorylation patterns created by GRK2 and GRK5 on the C-terminal tail of ACKR3 lead to distinct structural arrangements and dynamics of G-protein-coupled receptor–arrestin complexes, potentially explaining diverse cellular outcomes.

Qiuyan Chen
Christopher T. Schafer
John J. G. Tesmer
Research21 May 2025
Nature

Volume: 643, P: 280-287
Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

Yanyong Kang
Oleg Kuybeda
H. Eric Xu
Amendments and Corrections21 Jun 2018
Nature

Volume: 561, P: E44
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Hepatitis B and D viruses require docking to the NTCP receptor protein for cell entry, an interaction that can be blocked by the drug bulevirtide. Here the authors use cryo-EM to reveal the structural basis of bulevirtide activity.

Hongtao Liu
Dariusz Zakrzewicz
Kaspar P. Locher
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-13
RETRACTED ARTICLE: Mechanically interlocked architecture aids an ultra-stiff and ultra-hard elastically bendable cocrystal

Molecular crystals are typically less stiff than metals or ceramics. Here the authors report an organic elastically bendable co-crystal with stiffness comparable to low-density metals, hardness similar to stainless steel and reveal the molecular mechanism which lead to these mechanical properties.

Somnath Dey
Susobhan Das
C. Malla Reddy
ResearchOpen Access16 Aug 2019
Nature Communications

Volume: 10, P: 1-10
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

The cryo-electron microscopy structure of human rhodopsin bound to the inhibitory G_i protein-coupled receptor provides insights into ligand–receptor–G-protein interactions.

Yanyong Kang
Oleg Kuybeda
H. Eric Xu
Research13 Jun 2018
Nature

Volume: 558, P: 553-558
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels

Using cryo-EM structures, single-molecule fluorescence and electrophysiological studies, Kern et al. show how LRRC8A:C volume-regulated channels assemble into heteromers and use pore-bound lipids to block conduction in a closed state.

David M. Kern
Julia Bleier
Stephen G. Brohawn
Research16 Mar 2023
Nature Structural & Molecular Biology

Volume: 30, P: 841-852
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

Shahir S. Rizk
Somnath Mukherjee
Anthony A. Kossiakoff
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-6
Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Tryptophan C-mannosyltransferase (CMT) enzymes append a mannose to the first tryptophan of select sequences, which is important for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. A study reveals the structure, mode of peptide recognition and catalytic mechanism for the eukaryotic C-mannosyltransferase DPY19.

Joël S. Bloch
Alan John
Kaspar P. Locher
ResearchOpen Access05 Jan 2023
Nature Chemical Biology

Volume: 19, P: 575-584
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity

The post-translational modification O-GlcNAc on amyloid-forming proteins can inhibit their aggregation. Now, it has been shown that O-GlcNAc modification of small heat shock proteins HSP27, αA- and αB-crystallin can increase their anti-amyloid activity and block the amyloid formation of both α-synuclein and Aβ(1–42). A mechanism for this protective effect based on decreased physical interactions is also proposed.

Aaron T. Balana
Paul M. Levine
Matthew R. Pratt
Research15 Mar 2021
Nature Chemistry

Volume: 13, P: 441-450
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

Cryo-EM structures of complexes between GRK1 and rhodopsin shed light on how a small number of GRKs can selectively recognize and be activated by hundreds of different G-protein-coupled receptors.

Qiuyan Chen
Manolo Plasencia
John J. G. Tesmer
Research14 Jul 2021
Nature

Volume: 595, P: 600-605
Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer

Frances Willenbrock
Catrin M. Cox
Somnath Mukherjee
ResearchOpen Access26 Oct 2020
British Journal of Cancer

Volume: 124, P: 581-586
Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

Single particle cryo-electron microscopy of membrane proteins is limited by their small size and difficulty to orient. Here the authors generate recombinant antibodies against the 12 kDa fusion partner BRIL domain from apocytochrome b562 to use them as plug and play fiducial marks for structure determination of BRIL fused membrane proteins.

Somnath Mukherjee
Satchal K. Erramilli
Anthony A. Kossiakoff
ResearchOpen Access27 Mar 2020
Nature Communications

Volume: 11, P: 1-14
Retraction Note: Mechanically interlocked architecture aids an ultra-stiff and ultra-hard elastically bendable cocrystal

Somnath Dey
Susobhan Das
C. Malla Reddy
Amendments and CorrectionsOpen Access20 Oct 2021
Nature Communications

Volume: 12, P: 1
Role of nutritional status and intervention in oesophageal cancer treated with definitive chemoradiotherapy: outcomes from SCOPE1

S Cox
C Powell
Thomas David Lewis Crosby
ResearchOpen Access21 Jun 2016
British Journal of Cancer

Volume: 115, P: 172-177
The WHO estimates of excess mortality associated with the COVID-19 pandemic

Msemburi et al. describe how the World Health Organization has estimated the excess mortality associated with the COVID-19 pandemic, by month and for 2020 and 2021, and analyse their estimates across the WHO member states, with 14.83 million global excess deaths estimated.

William Msemburi
Ariel Karlinsky
Jon Wakefield
ResearchOpen Access14 Dec 2022
Nature

Volume: 613, P: 130-137
Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy

Arup Ranjan Patra
Somnath Singha Roy
Sudin Bhattacharya
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
Engineered isopeptide bond stabilized fibrin inspired nanoscale peptide based sealants for efficient blood clotting

Snehasish Ghosh
Sanchita Mukherjee
Rituparna Sinha Roy
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Reply to Comment on “The UK consensus position on the treatment of pancreatic cancer during the COVID-19 pandemic”

Christopher M. Jones
Ganesh Radhakrishna
Somnath Mukherjee
CorrespondenceOpen Access03 Nov 2020
British Journal of Cancer

Volume: 124, P: 679-680
Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position

Christopher M. Jones
Ganesh Radhakrishna
Somnath Mukherjee
ReviewsOpen Access08 Jul 2020
British Journal of Cancer

Volume: 123, P: 709-713
Graphene oxide-ferrite hybrid framework as enhanced broadband absorption in gigahertz frequencies

Rajarshi Bhattacharyya
Om Prakash
Santanu Das
ResearchOpen Access20 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

Hongtao Liu
Rossitza N. Irobalieva
Kaspar P. Locher
CorrespondenceOpen Access20 Jun 2022
Cell Research

Volume: 32, P: 773-776
Pentraxin 3 is a stromally-derived biomarker for detection of pancreatic ductal adenocarcinoma

Michelle R. Goulart
Jennifer Watt
Hemant M. Kocher
ResearchOpen Access29 Jun 2021
npj Precision Oncology

Volume: 5, P: 1-10

Search

Structural basis of drug recognition by human MATE1 transporter

Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial

Structure of human drug transporters OATP1B1 and OATP1B3

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor

Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

RETRACTED ARTICLE: Mechanically interlocked architecture aids an ultra-stiff and ultra-hard elastically bendable cocrystal

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

Retraction Note: Mechanically interlocked architecture aids an ultra-stiff and ultra-hard elastically bendable cocrystal

Role of nutritional status and intervention in oesophageal cancer treated with definitive chemoradiotherapy: outcomes from SCOPE1

The WHO estimates of excess mortality associated with the COVID-19 pandemic

Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy

Engineered isopeptide bond stabilized fibrin inspired nanoscale peptide based sealants for efficient blood clotting

Reply to Comment on “The UK consensus position on the treatment of pancreatic cancer during the COVID-19 pandemic”

Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position

Graphene oxide-ferrite hybrid framework as enhanced broadband absorption in gigahertz frequencies

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

Pentraxin 3 is a stromally-derived biomarker for detection of pancreatic ductal adenocarcinoma

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