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SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

An interfacial assembly strategy was developed to construct single-atom binary Fe/Co-Nx sites with a high accessible site density of 7.6 × 10¹⁹ sites per gram which results in increased power densities in fuel cells and Zn/air batteries.

A surface functionalization approach allows for preparing a nanostructured molecular protection layer, enabling stretchable polymer electronics that stably operate in physiological environments over 80 days.

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

CO₂ methanation offers a route to synthetic methane production but typically requires high temperatures to achieve sufficient rates. This study presents light-driven CO₂ methanation on an Au/Ce_0.95Ru_0.05O₂ solid-solution catalyst with high CH₄ production rate and selectivity benefiting from synergistic photochemical and photothermal effects.

The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle. Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with thermosensitive sol–gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model.

Aurora B kinase is a member of the chromosomal passenger complex, which is an indispensable regulator of mitosis. Here the authors show that the deubiquitinating enzyme USP35 has a role in mitotic progression by inhibiting proteasomal degradation of Aurora B kinase, leading to its activation.

The role of morphological alterations in the mitochondrial inner-membrane in regulating mitochondrial division are unknown. Here, the authors describe spontaneous and repetitive constriction of the mitochondrial inner compartment, and suggest this acts as a priming event for efficient mitochondrial division.

Oxygenated bicyclic cores are common to many natural and bioactive compounds, but their efficient synthesis can be difficult. Here, the authors report a gold-catalysed diastereoselective process for the synthesis of oxabicyclo[3.2.1]octanes via a domino process.

RNA-guided endonucleases (RGENs) are promising tools for genome editing, although their limited activity poses a challenge. Here the authors use surrogate reporters to achieve enrichment of cells containing RGEN-induced mutations up to 11-fold, which could help facilitate the use of RGENs in biomedical research.

Salicylate is a regulator of innate immunity to infection in plants. Here, Liu et al.show that two plant pathogens secrete enzymes that disrupt salicylate biosynthesis and plant immunity, and reveal that these effectors are secreted via an unconventional mechanism.

Parvalbumin-expressing interneurons regulate the activation and fate choice of adult neural stem cells.

Nematic and isotropic liquid phases can coexist within a narrow temperature window. Here, Kim et al. show how to control this mixed phase via thermal and dielectrophoretic manipulations, based on which nematic microfilaments in an isotropic medium, or vice versa, are demonstrated.

RuO₂ is a promising anode catalyst for proton exchange membrane water electrolyzers but suffers from poor catalytic stability. Here the authors present a rhenium-doped RuO₂ with a unique dynamic electron accepting-donating that adaptively boosts activity and stability in acidic water oxidation.

Gate-tunable heterojunction diodes—or triodes—that are based on van der Waals heterostructures formed from two-dimensional indium selenide and three-dimensional silicon can exhibit subthreshold slopes of 6.4 mV decade^–1 and on-state current densities of 0.3 µA µm^–1 at a drain bias of –1 V.

The authors achieved the X-ray-excited organic phosphorescent scintillation from copolymers through copolymerization of bromine-substituted chromophores and acrylic acid and demonstrated their potential application in X-ray radiography.

Fabrication of a low-dimensional metal halide perovskite superlattice by chemical epitaxy is reported, with a criss-cross two-dimensional network parallel to the substrate, leading to efficient carrier transport in three dimensions.

A method for mapping phonon momenta reveals non-equilibrium phonon dynamics at nanoscale interfaces enabling study of actual nanodevices and aiding understanding of heat dissipation near nanoscale hotspots.

Lithium metal batteries (LMBs) with inorganic solid-state electrolytes suffer from lithium dendrites propagation. Here, the authors demonstrate the production of stable lab-scale LMBs using an Ag-coated Li_6.4La₃Zr_1.7Ta_0.3O₁₂ inorganic solid electrolyte in combination with a silver-carbon interlayer.

Natural adhesives have received a lot of attention recently. Here, the authors develop a natural biological adhesive from snail mucus that can adhere to wet tissue and be used to accelerate healing of skin wounds.

While homodimeric prodrug assemblies can improve drug loading and limit toxicity in cancer therapy, bioactivation within the target site is limited. Here, the authors introduce a hybrid chalcogen bond linker to a docetaxel dimeric prodrug nanoassembly and demonstrate its improved selfassembly, redox-responsivity and antitumor efficacy.

Persistent low-velocity baryonic jets have been detected from a supersoft X-ray source; the low velocity suggests that these jets have not been launched from a white dwarf, and the persistence speaks against the origin being a canonical black hole or neutron star, indicating that a different type of source must be implicated.

Both a pipe-clip-device structure and an effective air-gap fabrication technique allow for a nanomechanical switch to be synthesized that can be operated with less than 1 V.

Electric fields are shown to act as directional cues for cell migration during wound healing, and the signalling pathways involved are elucidated.

How interhemispheric connections are organized and how interhemispheric communication are regulated are not fully understood. Here authors delineate the diverse single-neuron projection patterns of interhemispheric connections in mice and uncover their influence on functional dynamics, highlighting the importance of heterotopic projections in interhemispheric communication.

Insight-HXMT detected a double-peaked X-ray burst from Galactic magnetar SGR J1935+2154, consistent with two fast radio bursts (FRBs) observed from the same object within seconds. This coincidence suggests a common physical origin, and gives insight into the mechanism behind the origin of FRBs.

It has been proposed that, during development, clonally related neurons migrate along the same radial glial fibre to form clusters of functionally similar cells; here, sister neurons in the same radial clone are shown to have similar orientation preferences in mice, providing support for this hypothesis.

How the East Asian Summer Monsoon has changed over the Holocene has been debated, as some proxy records disagree with each other. Here, the authors suggest that monsoonal rainfall peaked in the early Holocene, while ecosystem responses peaked in the mid-Holocene, explaining the differences between records.

Novel dry electrodes with enhanced mechano-electrical stability and conformability are attractive for long-time electrophysiological signal monitoring. Here, the authors report polymer-covered CVD-grown graphene with enhanced optoelectronic performance for biopotential monitoring.