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Showing 1–5 of 5 results
Advanced filters: Author: Sowndarya Muthukumar Clear advanced filters

  • Crystal structures, along with biochemistry data, capture the active form of the Dcp2 decapping enzyme in complex with Dcp1 and a peptide from Edc1, thus revealing the mechanism of activation by Dcp1 and Edc1 activators.

    • Eugene Valkov
    • Sowndarya Muthukumar
    • Elisa Izaurralde
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 574-579

  • Bellodi, Dimitriou and colleagues report that pseudouridine-modified transfer-RNA fragments modulate the translation of transcripts sharing pyrimidine-enriched sequences at their 5′ untranslated regions and their dysregulation impacts myelodysplastic syndrome pathogenesis.

    • Nicola Guzzi
    • Sowndarya Muthukumar
    • Cristian Bellodi
    ResearchOpen Access
    Nature Cell Biology
    Volume: 24, P: 299-306

  • The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and RNA binding proteins in targeted deadenylation.

    • Tobias Raisch
    • Chung-Te Chang
    • Eugene Valkov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • tRNA-derived small RNAs (tdRs) have long been considered mere intermediates of tRNA degradation. This Review discusses the biogenesis and regulation of tdRs and focuses on their emerging gene regulation roles in cell metabolism, immune responses, development and cancer.

    • Sowndarya Muthukumar
    • Cai-Tao Li
    • Cristian Bellodi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 359-378

  • The editing domain of aminoacyl-tRNA synthetases is responsible for removing non-cognate amino acids from mischarged tRNAs. Here the authors show that the D-aminoacyl-tRNA deacylase fold of archaeal ThrRS does not rely on protein side chains for substrate specificity and catalysis.

    • Sadeem Ahmad
    • Sowndarya Muthukumar
    • Rajan Sankaranarayanan
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12