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Advanced filters: Author: Srimayee Vaidyanathan Clear advanced filters

  • Identifying genes involved in MYC-driven lymphoma reveals therapeutic vulnerabilities. Here, the authors show by using CRISPR knockout screens in primary cells in vivo that the GATOR1 complex suppresses MYC-driven lymphomagenesis, and that GATOR1-deficient lymphomas are sensitive to mTOR inhibitors.

    • Margaret A. Potts
    • Shinsuke Mizutani
    • Marco J. Herold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14