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Showing 1–3 of 3 results
Advanced filters: Author: Stacy J. Vasquez Clear advanced filters

  • Haspin phosphorylates histone H3 threonine 3 (H3T3) to ensure proper progression through mitosis. Here the authors describe how Haspin engages a nucleosomal DNA supergroove, using electrostatic interactions, thereby promoting H3T3 phosphorylation.

    • Chad W. Hicks
    • Colin R. Gliech
    • Cynthia Wolberger
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1030-1037

  • Metaplastic breast cancer is a highly chemoresistant breast cancer subtype with limited therapeutic options. Here, the authors report that the NOS inhibitor, L-NMMA, sensitises metaplastic breast cancer to a selective PI3K inhibitor, alpelisib, and taxane chemotherapy via repression of c-JUN mediated epithelial-to-mesenchymal transition.

    • Tejaswini Reddy
    • Akshjot Puri
    • Jenny Chang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

    • Sunil K. Ahuja
    • Muthu Saravanan Manoharan
    • Weijing He
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-31