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Showing 1–2 of 2 results
Advanced filters: Author: Stavros Taraviras Clear advanced filters

  • Re-replication is a driving force of tumorigenesis and genomic instability. Here, the authors show that upon re-replication, FANCD2 localizes at early origins to limit replisome progression, ssDNA gap accumulation and fork breakage, revealing a vulnerability for selective targeting of cancer cells.

    • Nibal Badra-Fajardo
    • Elena Karydi
    • Zoi Lygerou
    ResearchOpen Access
    Nature Communications
    P: 1-22

  • Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.

    • Antonia Marazioti
    • Ioannis Lilis
    • Georgios T. Stathopoulos
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16