Here the researchers report that 5’tRFGlu(CTC), a tRNA-derived fragment, is associated with diabetes and mediates pancreatic beta cell and macrophage responses to nutritional stress. targeted inhibition of 5’tRFGlu(CTC) preserves beta cell viability and function under lipotoxic exposure.
- Cristina Cosentino
- Rémy Klein
- Romano Regazzi
