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Showing 1–14 of 14 results
Advanced filters: Author: Steffen N. Lindner Clear advanced filters

  • The need for redox balancing limits the array of fermentable substrate-product combinations in anaerobic microbe-based bioproduction. Here, the authors design and engineer an E. coli strain with new-to-nature aerobic fermentative metabolism that allows tightly controlled re-balanced fermentations.

    • Helena Schulz-Mirbach
    • Jan Lukas Krüsemann
    • Steffen N. Lindner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for sensing glyoxylate and glycolate, with applications in pathway engineering and environmental monitoring.

    • Enrico Orsi
    • Helena Schulz-Mirbach
    • Pablo I. Nikel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • One-carbon substrates are attractive feedstocks for circular bioeconomy. Here, the authors design an erythrulose monophosphate (EuMP) cycle for formaldehyde assimilation, demonstrate the activity of the core reactions in E. coli, and show its integration with pathway reactions existed in pentose phosphate pathway and glycolysis.

    • Tong Wu
    • Paul A. Gómez-Coronado
    • Hai He
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with cellular redox homeostasis, this approach enables the precise tuning of metabolic pathways and the optimization of microbial bioproduction, independently of canonical redox balancing.

    • Lena M. Hümmler
    • Steffen N. Lindner
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 1395-1396

  • Current efforts to establish synthetic carbon fixation in model heterotrophs rely on expression of heterologous enzymes. Here, the authors explore the presence and activity of a latent CO2-assimilation pathway in E. coli based only on endogenous enzymes and a reversible decarboxylase.

    • Ari Satanowski
    • Beau Dronsella
    • Arren Bar-Even
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The future of bioproduction lies in efficient C1 utilization. Methanol derived from CO2 can be fed to engineered bacteria that convert it into platform chemicals currently produced from fossil fuels. Now, recent results confirm we are getting closer.

    • Jan Lukas Krüsemann
    • Steffen N. Lindner
    News & Views
    Nature Catalysis
    Volume: 7, P: 472-474

  • Redesigning the central carbon metabolism of Escherichia coli with the reductive glycine pathway enables growth on the one-carbon compounds formate and CO2, and the addition of methanol dehydrogenase further enables growth on methanol and CO2.

    • Seohyoung Kim
    • Steffen N. Lindner
    • Arren Bar-Even
    Research
    Nature Chemical Biology
    Volume: 16, P: 538-545

  • Achieving cost-competitive bio-based processes requires development of stable and selective biocatalysts. In this Perspective, the authors propose an integrated solution combining growth-coupled selection with machine learning and automated workflows to accelerate development pipelines.

    • Enrico Orsi
    • Lennart Schada von Borzyskowski
    • Steffen N. Lindner
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The core metabolic pathways are tightly intertwined, creating challenges for metabolic engineering. Yu et al. present a synthetic decarboxylation cycle that substitutes the TCA cycle in energy metabolism, gaining high yields in the production of reduced compounds such as fatty acids.

    • Steffen N. Lindner
    • Markus Ralser
    News & Views
    Nature Metabolism
    Volume: 4, P: 1438-1439

  • Some Aβ peptides contain pyroglutamate modifications that affect the aggregation properties of these peptides. The authors find that the enzyme glutaminyl cyclase is responsible for this pyroglutamate modification. When they inhibit the enzyme in Alzheimer's model mice, fewer plaques form in the brain, and some measures of learning and memory are improved.

    • Stephan Schilling
    • Ulrike Zeitschel
    • Steffen Rossner
    Research
    Nature Medicine
    Volume: 14, P: 1106-1111

  • Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.

    • Enrico Orsi
    • Nico J. Claassens
    • Steffen N. Lindner
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-5