Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.
- Mehrnoosh Jafari
- Adrian-Minh Schumacher
- Martin Kerschensteiner
